Flashcards in Autoimmune Disorders: RA Deck (34):
1
What type of disorder is RA?
chronic, systemic inflammatory disorder
2
What causes RA?
unknown
3
What tissues does RA predominately affect?
synovial tissues
4
Who gets RA most often?
women affected 2x more than men
5
RA is most commonly dx between:
20 and 40 y.o.
6
Predominance of cases diagnosed after 60 y.o.
⅓
7
What are 2 risk factors for RA?
- specific gene on chromosome 6
- encounters some agent, RA expressed
8
When and how much joint erosion occurs?
90% of pts have significant joint erosion within 2 years of dx
early intervention is KEY
9
What is the acronym for clinical s/s of dx RA
SERIOUS
10
SERIOUS: S
S
Swelling in joints
11
SERIOUS: E
E
Early AM stiffness
12
SERIOUS: R
R
Recurring pain/tenderness in any joint
13
SERIOUS: I
I
Inability to move a joint normally
14
SERIOUS: O
O
Obvious redness and warmth
15
SERIOUS: U
U
Unexplained stuff
16
What is some of the unexplained stuff from RA?
- weight loss
- fever
- weakness with joint pain
17
SERIOUS: S (second S)
S
Symptoms lasting longer than 2 weeks
18
Proportion of people diagnosed at a younger age
⅔ of people dx at a younger age
19
Younger (30-50): who gets this?
2:1 ratio of women to men
20
Older (60+): who gets this?
equal ratio women to men
21
Younger (30-50): joint involvement (#)
polyarticular
22
Older (60+): joint involvement (#)
oligoarticular
23
Younger (30-50): which joints are involved?
small joints
24
Older (60+): which joints are involved?
large joints
25
Younger (30-50): onset
gradual onset
26
Older (60+): onset
abrupt onset
27
Younger (30-50): RF
positive RF
28
Older (60+): RF
negative RF
29
What is a huge red flag for RA?
cervical spine involvement
30
When does c-spine involvement occur with RA?
occurs in advanced disease
31
What is the first sign of c-spine involvement with RA?
global cervical spine stiffness
32
What causes cervical laxity seen with RA?
inflammation of supporting ligaments
33
Implications of c-spine laxity with RA?
- C1-C2
- may get atlantoaxial subluxation
- can get SC compression
34