Flashcards in Autoimmune Disorders: RA Deck (34)
What type of disorder is RA?
chronic, systemic inflammatory disorder
What causes RA?
What tissues does RA predominately affect?
Who gets RA most often?
women affected 2x more than men
RA is most commonly dx between:
20 and 40 y.o.
Predominance of cases diagnosed after 60 y.o.
What are 2 risk factors for RA?
- specific gene on chromosome 6
- encounters some agent, RA expressed
When and how much joint erosion occurs?
90% of pts have significant joint erosion within 2 years of dx
early intervention is KEY
What is the acronym for clinical s/s of dx RA
Swelling in joints
Early AM stiffness
Recurring pain/tenderness in any joint
Inability to move a joint normally
Obvious redness and warmth
What is some of the unexplained stuff from RA?
- weight loss
- weakness with joint pain
SERIOUS: S (second S)
Symptoms lasting longer than 2 weeks
Proportion of people diagnosed at a younger age
⅔ of people dx at a younger age
Younger (30-50): who gets this?
2:1 ratio of women to men
Older (60+): who gets this?
equal ratio women to men
Younger (30-50): joint involvement (#)
Older (60+): joint involvement (#)
Younger (30-50): which joints are involved?
Older (60+): which joints are involved?
Younger (30-50): onset
Older (60+): onset
Younger (30-50): RF
Older (60+): RF
What is a huge red flag for RA?
cervical spine involvement
When does c-spine involvement occur with RA?
occurs in advanced disease
What is the first sign of c-spine involvement with RA?
global cervical spine stiffness
What causes cervical laxity seen with RA?
inflammation of supporting ligaments
Implications of c-spine laxity with RA?
- may get atlantoaxial subluxation
- can get SC compression