Autoimmune Disorders: RA Flashcards Preview

8501 Clin Med > Autoimmune Disorders: RA > Flashcards

Flashcards in Autoimmune Disorders: RA Deck (34):
1

What type of disorder is RA?

chronic, systemic inflammatory disorder

2

What causes RA?

unknown

3

What tissues does RA predominately affect?

synovial tissues

4

Who gets RA most often?

women affected 2x more than men

5

RA is most commonly dx between:

20 and 40 y.o.

6

Predominance of cases diagnosed after 60 y.o.

7

What are 2 risk factors for RA?

- specific gene on chromosome 6
- encounters some agent, RA expressed

8

When and how much joint erosion occurs?

90% of pts have significant joint erosion within 2 years of dx

early intervention is KEY

9

What is the acronym for clinical s/s of dx RA

SERIOUS

10

SERIOUS: S

S

Swelling in joints

11

SERIOUS: E

E

Early AM stiffness

12

SERIOUS: R

R

Recurring pain/tenderness in any joint

13

SERIOUS: I

I

Inability to move a joint normally

14

SERIOUS: O

O

Obvious redness and warmth

15

SERIOUS: U

U

Unexplained stuff

16

What is some of the unexplained stuff from RA?

- weight loss
- fever
- weakness with joint pain

17

SERIOUS: S (second S)

S

Symptoms lasting longer than 2 weeks

18

Proportion of people diagnosed at a younger age

⅔ of people dx at a younger age

19

Younger (30-50): who gets this?

2:1 ratio of women to men

20

Older (60+): who gets this?

equal ratio women to men

21

Younger (30-50): joint involvement (#)

polyarticular

22

Older (60+): joint involvement (#)

oligoarticular

23

Younger (30-50): which joints are involved?

small joints

24

Older (60+): which joints are involved?

large joints

25

Younger (30-50): onset

gradual onset

26

Older (60+): onset

abrupt onset

27

Younger (30-50): RF

positive RF

28

Older (60+): RF

negative RF

29

What is a huge red flag for RA?

cervical spine involvement

30

When does c-spine involvement occur with RA?

occurs in advanced disease

31

What is the first sign of c-spine involvement with RA?

global cervical spine stiffness

32

What causes cervical laxity seen with RA?

inflammation of supporting ligaments

33

Implications of c-spine laxity with RA?

- C1-C2
- may get atlantoaxial subluxation
- can get SC compression

34

Referral with RA and c-spine issues

must have an immediate referral!

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