9.19 Injury, Inflammation, Healing 2 Flashcards Preview

8501 Clin Med > 9.19 Injury, Inflammation, Healing 2 > Flashcards

Flashcards in 9.19 Injury, Inflammation, Healing 2 Deck (26):
1

Both acute and chronic cell injury can be

reversible

2

impaired cell function and ion content for an acute reversible injury with sublethal stimulus

- increased ion content (Na+ and Ca2+)
- cell swells due to fluid retention

3

blebs

plasma membrane seals off and detaches

4

If this survives, the cell can recover

nucleus

5

What are the typical ways a cell adapts?

- atrophy
- hypertrophy
- hyperplasia
- metaplasia
- dysplasia

6

Chronic adaptation allows the body to

survive in an altered environment and avoid injury

7

What do intracellular accumulations do?

alter cell function

8

What types of things can accumulate in cells?

- lipids
- proteins
- carbs
- pigment

9

example of an intracellular accumulation

hepatocytes

10

hepatocytes are often seen in

fatty liver with alcohol abuse

11

Irreversible injury leads to

cell death

12

apoptosis

programmed cell death

13

necrosis

end point of degradation of cells

14

What are the 3 types of necrosis?

- dry gangrene
- wet gangrene
- gas gangrene

15

dry gangrene

- bacterial infection
- ischemia

16

wet gangrene

liquefactive tissue

17

gas gangrene

fermentation forms gas bubbles

18

What are the irreversible cell injury types?

- apoptosis
- necrosis
- calcification

19

examples of calcification

- atherosclerosis
- TB (granulomas)
- calcific tendonitis

etc.

20

Dry vs. wet gangrene: infection?

- dry: no
- wet: yes

21

Dry vs. wet gangrene: tissue liquefaction?

- dry: no
- wet: copious

22

How does wet gangrene develop?

Usually develops rapidly due to blockage of venous and/or arterial blood flow

23

Early stages of dry gangrene

- dull, achy pain
- extreme ttp
- cold, dry, wrinkled

24

Later stages of dry gangrene

skin changes color gradually to
- dark brown
- dark purplish blue
- black

25

tx for gangrene

- surgical debridement
- amputation

26

wet gangrene: odor and appearance

- swollen, red, warm
- offensive odor

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