Flashcards in 9.19 Injury, Inflammation, Healing 2 Deck (26)
Both acute and chronic cell injury can be
impaired cell function and ion content for an acute reversible injury with sublethal stimulus
- increased ion content (Na+ and Ca2+)
- cell swells due to fluid retention
plasma membrane seals off and detaches
If this survives, the cell can recover
What are the typical ways a cell adapts?
Chronic adaptation allows the body to
survive in an altered environment and avoid injury
What do intracellular accumulations do?
alter cell function
What types of things can accumulate in cells?
example of an intracellular accumulation
hepatocytes are often seen in
fatty liver with alcohol abuse
Irreversible injury leads to
programmed cell death
end point of degradation of cells
What are the 3 types of necrosis?
- dry gangrene
- wet gangrene
- gas gangrene
- bacterial infection
fermentation forms gas bubbles
What are the irreversible cell injury types?
examples of calcification
- TB (granulomas)
- calcific tendonitis
Dry vs. wet gangrene: infection?
- dry: no
- wet: yes
Dry vs. wet gangrene: tissue liquefaction?
- dry: no
- wet: copious
How does wet gangrene develop?
Usually develops rapidly due to blockage of venous and/or arterial blood flow
Early stages of dry gangrene
- dull, achy pain
- extreme ttp
- cold, dry, wrinkled
Later stages of dry gangrene
skin changes color gradually to
- dark brown
- dark purplish blue
tx for gangrene
- surgical debridement