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8501 Clin Med > Viruses/Fungi 5 > Flashcards

Flashcards in Viruses/Fungi 5 Deck (35)
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1

STI prevalence

~ 56 million (1 in 4) carry an STI other than HIV

2

causes of STIs

- bacteria
- viruses
- parasites

3

How are STIs spread?

- shared drug paraphernalia
- sexual contact

4

Implications for healthcare workers: STIs

contact precautions

5

What are the drugs that treat HSV I and II?

- Acyclovir
- Valacyclovir
- Penciclovir
- Docosanol

6

Docosanol aka

Abreva

7

Valacyclovir aka

Valtrex

8

How does Abreva work?

- acts on host cells so that viral adsorption is inhibited
- doesn't act on virus

9

When should Abreva be used?

- as early as possible
- before virus can replicate

10

Adverse effects of Abreva?

- HA
- local irritation

11

topical meds for HSV

- Abreva (docosanol)
- penciclovir (denavir)

12

topical administration of HSV drugs

- cutaneous infections
- mucosal infections

13

Oral/IV administration: Valacyclovir

- taken orally for better absorption
- converts to acyclovir in the bloodstream

14

Valacyclovir is a prodrug of

acyclovir

15

What are some systemic adverse effects of oral/IV drugs for HSV?

- HA
- dizziness
- GI issues

16

What are some of the influenza A drugs? How are they administered?

- Amantadine
- Rimantadine

orally

17

Amantadine =

Symmetrel

18

Rimantadine =

Flumadine

19

In addition to flu, Amantadine is also useful for these

- motor abnormalities of Parkinsons
- possibly blocks excitatory NT in BG

20

Effectiveness of influenza A drugs

- can be 70-90% effective in preventing influenza A if used prophylactically
- can lessen effects of infection if given when symptoms first appear

21

adverse effects of influenza A meds

- CNS symptoms
- seizures with overdoses

22

CNS issues with influenza A drugs

- confusion
- loss of concentration
- lightheadedness
- mood changes

23

What can occur with AIDS? (herpesviruses)

CMV retinitis

24

Drugs that treat CMV retinitis? How are they administered?

- Cidofovir
- IV

25

CMV retinitis drugs: What are some adverse effects?

- nephrotoxic
- neutropenia

26

How does neutropenia happen with CMV drugs?

decreased neutrophilic leukocytes

27

Signs of neutropenia

- fever
- chills
- sore throat

28

What are some GI side effects of neutropenia?

- nausea
- diarrhea
- anorexia

29

Drugs for RNA and DNA viruses

Ribavirin

30

Ribavirin =

Virazole

31

What does ribavarin treat?

respiratory synctial virus (RSV)

32

What is RSV?

causes severe pneumonia

33

Who gets RSV?

- infants
- young children
- elderly
- immunosuppressed

34

How is Ribavirin administered?

aerosol inhalation

35

Adverse effects of Ribavirin

very few

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