Flashcards in 9.29 Immunity 5 Deck (26)
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1
How is the immune response modulated?
- immune suppression
- immunostimulants
2
Why would immune suppression be used?
- prevent rejection of transplanted organs/tissues
- limit immune-mediated damage to the body's tissues (suppress autoimmune response)
3
Immunostimulants are beneficial for
- compromised immune function
- chronic infections
4
Complex: may result in resemblance of autoimmune disease
immunostimulants
5
Which are used more commonly? Immunosuppressants or immunostimulants?
immunosuppressants
6
Antibodies, Azathioprine, Cyclosporine, Glucocorticoids, Methotrexate, and Prograv (tacrolymus) are all:
immunosuppressants
7
Antibodies are used in:
- prevention of bone marrow transplant rejection
- hemolytic disorders
8
Azathioprine is used for:
- prevention of transplant rejection
- RA
- IBS
- MG
- lupus
9
Cyclosporine is used for:
- prevention of transplant rejection
- RA
- psoriasis
10
Glucocorticoids are used for:
- transplant rejection
- MS
- RA
- hemolytic disorders
11
Methotrexate is used for:
- RA
- psoriasis
12
Prograv (tacrolymus) is used a lot with this
liver transplants for rejection
13
These are the big intense anti-inflammatory agents that cause big immune suppression
glucocorticoids
14
What is leukopenia?
leukocyte formation is suppressed
15
General adverse effects of immunosuppressants?
- leukopenia
- GI distress
- organ toxicities (nephrotoxicity)
- increased infections
16
What are adverse effects of glucocorticoids (immunosuppressants)
- breakdown of collagenous tissue
- growth retardation in children
- etc.
17
What are the immunostimulants?
- Bacille Calmette-Guerin
- Immune Globulin
18
What is Bacille Calmette-Guerin?
- active bacterial strain used as a vaccine against TB
- administered locally in the bladder for the tx of bladder cancer
19
Most common use for Bacille Calmette-Guerin
bladder cancer
20
adverse rxns for Bacille Calmette-Guerin?
- irritation at injection site
- skin irritation
- infection
21
How is immune globulin prepared?
by extracting immunoglobulins from donated human blood
22
Immune Globulin is primarily
IgG
23
How is Immune Globulin administered and what is its primary function?
- via IV
- immunodeficiency syndromes, Guillain-Barré, relapsing remitting MS
24
adverse rxns for Immune Globulin
- joint and muscle pain
- HA
- malaise
- Gi disturbance
25
Clients with autoimmune disorders taking immunosuppressants will likely be (better/worse) able to participate in PT?
better able to participate
26
