9.29 Immunity 5 Flashcards Preview

8501 Clin Med > 9.29 Immunity 5 > Flashcards

Flashcards in 9.29 Immunity 5 Deck (26)
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1

How is the immune response modulated?

- immune suppression
- immunostimulants

2

Why would immune suppression be used?

- prevent rejection of transplanted organs/tissues
- limit immune-mediated damage to the body's tissues (suppress autoimmune response)

3

Immunostimulants are beneficial for

- compromised immune function
- chronic infections

4

Complex: may result in resemblance of autoimmune disease

immunostimulants

5

Which are used more commonly? Immunosuppressants or immunostimulants?

immunosuppressants

6

Antibodies, Azathioprine, Cyclosporine, Glucocorticoids, Methotrexate, and Prograv (tacrolymus) are all:

immunosuppressants

7

Antibodies are used in:

- prevention of bone marrow transplant rejection
- hemolytic disorders

8

Azathioprine is used for:

- prevention of transplant rejection
- RA
- IBS
- MG
- lupus

9

Cyclosporine is used for:

- prevention of transplant rejection
- RA
- psoriasis

10

Glucocorticoids are used for:

- transplant rejection
- MS
- RA
- hemolytic disorders

11

Methotrexate is used for:

- RA
- psoriasis

12

Prograv (tacrolymus) is used a lot with this

liver transplants for rejection

13

These are the big intense anti-inflammatory agents that cause big immune suppression

glucocorticoids

14

What is leukopenia?

leukocyte formation is suppressed

15

General adverse effects of immunosuppressants?

- leukopenia
- GI distress
- organ toxicities (nephrotoxicity)
- increased infections

16

What are adverse effects of glucocorticoids (immunosuppressants)

- breakdown of collagenous tissue
- growth retardation in children
- etc.

17

What are the immunostimulants?

- Bacille Calmette-Guerin
- Immune Globulin

18

What is Bacille Calmette-Guerin?

- active bacterial strain used as a vaccine against TB
- administered locally in the bladder for the tx of bladder cancer

19

Most common use for Bacille Calmette-Guerin

bladder cancer

20

adverse rxns for Bacille Calmette-Guerin?

- irritation at injection site
- skin irritation
- infection

21

How is immune globulin prepared?

by extracting immunoglobulins from donated human blood

22

Immune Globulin is primarily

IgG

23

How is Immune Globulin administered and what is its primary function?

- via IV
- immunodeficiency syndromes, Guillain-Barré, relapsing remitting MS

24

adverse rxns for Immune Globulin

- joint and muscle pain
- HA
- malaise
- Gi disturbance

25

Clients with autoimmune disorders taking immunosuppressants will likely be (better/worse) able to participate in PT?

better able to participate

26

What is critically important with an immunosuppressed pt and PT?

- make sure tx space is clean
- avoid introducing pathogens

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