Study Guide 3 Flashcards Preview

8501 Clin Med > Study Guide 3 > Flashcards

Flashcards in Study Guide 3 Deck (22):
1

What are some of the major symptoms that can occur with SSRIs?

- tremors
- anxiety
- orthostatic hypotension
- serotonin syndrome

2

In addition to SSRIs, what other drugs may cause serotonin syndrome?

SNRIs

3

What causes serotonin syndrome?

Too much serotonin in brain tissue

4

What are the s/s of serotonin syndrome?

- sweating
- restlessness
- agitation
- tachycardia
- NM hyperexcitability

5

What do we mean by NM hyperexcitability?

- clonus
- tremor
- fasciculation
- rigidity

6

Dangers of serotonin syndrome

- DEADLY
- danger of seizures

7

When might a pt get serotonin syndrome?

- high doses of drugs
- 2 or more antidepressants at once

8

Serotonin syndrome: reversible?

Yes - if drugs are withdrawn

9

What are some of the major side effects of MAOIs?

- CNS excitation
- agitation
- irritability
- sleeplessness
- central/peripheral anticholinergic effects
- increased BP
- interactions

10

What are the Central/Peripheral anticholinergic effects seen with MAOIs?

- tremor
- dry mouth
- urinary retention

11

What can MAOIs have adverse interactions with?

- food
- caffeine/stimulants
- LOTS OF OTHER DRUGS

12

Drugs that cause the most problems with MAOIs

- alcohol
- sleepy meds
- other antidepressants

13

What foods do MAOIs interact with negatively?

fermented cheese/wine

14

How do MAOIs interact with fermented cheese/wine?

- increase catecholamines
- cause MI/stroke

15

Major adverse rxns associated with lithium

- seizures
- coma
- death
- sedation, muscle weakness, lethargy

16

Sedation, lethargy, muscle weakness seen with lithium is also seen with a this drug class

Tricyclics

17

What should a pt on the neuro drugs never do?

Never stop taking them abruptly

18

Why must these drugs never be stopped abruptly?

- alter biochemistry
- may cause adverse effects

19

Special considerations for these neuro drugs with rehab

- get list of ALL meds
- pt will gradually reach therapeutic level
- therapy timing

20

Rehab considerations: list of meds

- Rx and OTC
- note any changes or additions

21

Rehab considerations: time to reach therapeutic level

This will be reached within 2-4 weeks

22

Rehab considerations: therapy timing

- shouldn't matter if pt is at therapeutic level
- watch for orthostatic hypotension with tricyclics and lithium, especially in early stages and with the elderly

Decks in 8501 Clin Med Class (102):