Ciccone Doc for Pharm

Question 1

selective toxicity

Answer 1

• kills or attenuates pathogen growth

- no excessive damage to host

Question 2

Bacteria are structurally capable of independent life, but need this

Answer 2

nourishing host

Question 3

Broad spectrum antibacterial agents

Answer 3

• kill everything

- no specificity

Question 4

What does the lack of specificity of broad spectrum antibacterial agents lead to?

Answer 4

• less effective later on

- some bacteria will already have a tolerance built up

Question 5

bactericidal

Answer 5

• is bacteriostatic

- limits growth and proliferation

Question 6

Why is it common to see N/V with antibiotics?

Answer 6

they’re cleaning out intestinal flora

Question 7

When can drug resistance occur? What does this mean?

Answer 7

• can occur with overprescription of antibiotics

- must be mindful of prescribing so that it won’t have such a huge impact

Question 8

Basic mechanisms of action: Where do antibacterial agents differ?

Answer 8

location at which they impact the bacteria

Question 9

Where might antibacterial agents act?

Answer 9

• cell membrane synthesis
• cell wall synthesis
• inhibit protein synthesis
• inhibit DNA/RNA synthesis

Question 10

What are the drugs that act on cell membrane synthesis?

Answer 10

• Penicillins
• Cephalosporins
• Carbapenems

Question 11

What are the drugs that act on cell wall synthesis?

Answer 11

• Topical (i.e. bacitracin)

- Vancomycin

Question 12

What are the drugs that act on protein synthesis?

Answer 12

• Erythromycin
• Tetracycline
• Chloromycetin
• Clindamycin
• Ketek

Question 13

What are the drugs that act on DNA/RNA synthesis?

Answer 13

• Fluoroquinolones

- Sulfanomides