Flashcards in 9.7 Pharmacology 3 Deck (19):
1
dose-response curve
dosage range over which the drug is effective, including peak response
2
threshold dose
beginning of therapeutic response
3
ceiling effect
no further increase in response
4
What does the dose-response give indication of?
binding to cellular receptors
5
potency
dose that produces a given response in a specific amplitude
6
Drug A may have an effect at 10 mg, Drug B may require 80 mg to achieve same effect.
Which is more potent?
Drug A
less needed to provide the same response
7
Potency does NOT predict
therapeutic effect
8
quantal dose-response curve
percentage of the population that exhibits a specific response as the dosage is increased
9
grading of quantal dose-response curve
not graded
either present or absent in each member of the population
10
dose at which 50% of the population responds to the drug in a specified manner
median effective dose (ED_50)
11
dose at which 50% of the population exhibits an adverse effect
median toxic dose (TD_50)
12
dose which causes death of 50% of the animal test population
median lethal dose (LD_50)
13
What is a major indicator of drug safety?
therapeutic index
14
Large TI indicates:
a much larger dose is needed to evoke a toxic effect than it does to cause a therapeutic effect
15
TI =
TI = (TD_50)/(ED_50)
16
TI does not take these effects into account
long term
17
Tylenol has a TI of
27
*shows liver toxicity with prolonged use
18
diazepam (valium) has a TI of
3
19