9.7 Pharmacology 3 Flashcards Preview

8501 Clin Med > 9.7 Pharmacology 3 > Flashcards

Flashcards in 9.7 Pharmacology 3 Deck (19):
1

dose-response curve

dosage range over which the drug is effective, including peak response

2

threshold dose

beginning of therapeutic response

3

ceiling effect

no further increase in response

4

What does the dose-response give indication of?

binding to cellular receptors

5

potency

dose that produces a given response in a specific amplitude

6

Drug A may have an effect at 10 mg, Drug B may require 80 mg to achieve same effect.

Which is more potent?

Drug A

less needed to provide the same response

7

Potency does NOT predict

therapeutic effect

8

quantal dose-response curve

percentage of the population that exhibits a specific response as the dosage is increased

9

grading of quantal dose-response curve

not graded

either present or absent in each member of the population

10

dose at which 50% of the population responds to the drug in a specified manner

median effective dose (ED_50)

11

dose at which 50% of the population exhibits an adverse effect

median toxic dose (TD_50)

12

dose which causes death of 50% of the animal test population

median lethal dose (LD_50)

13

What is a major indicator of drug safety?

therapeutic index

14

Large TI indicates:

a much larger dose is needed to evoke a toxic effect than it does to cause a therapeutic effect

15

TI =

TI = (TD_50)/(ED_50)

16

TI does not take these effects into account

long term

17

Tylenol has a TI of

27

*shows liver toxicity with prolonged use

18

diazepam (valium) has a TI of

3

19

Drugs with a (low/high) TI are riskier

low

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