Flashcards in Study Guide 8 Deck (29)
Predisposition to psychiatric disorders (short and long lived aspects)
Medical impact on predisposition to psychiatric disorders
hormonal impact on predisposition to psychiatric disorders
SAD and PPD
Seasonal affective disorder
How does depression occur at the cellular level?
- decreased activity of postsynaptic receptor
- supersensitivity of the presynaptic autoreceptor
- decreased capacity for neurogenesis
- decreased activity of BDNF
What would cause decreased activity of the postsynaptic receptor?
- Decreased receptor presence
- decreased NT availability
With depression, what causes decreased capacity for neurogenesis?
High glucocorticoid levels = stress
Brain derived neurotropic factor
What is BDNF?
BDNF activates neurogenesis here (especially)
Hippocampus (and other areas)
BDNF is a major player in:
How does BDNF influence creation of new neurons?
- cell division
- migration of stem cells in the brain
BDNF is activated by
What increases synthesis of BDNF?
Increased activity of neurotransmitters
What are the goals of using pharmacology to great depression/psychiatric disorders?
- inhibit breakdown of NT
- stimulate release of NT
- block reuptake of NT
What are the BIG THREE neurotransmitters implicated in psychiatric disorders?
How does tx with antidepressants change the brain?
- growth of dendritic spines
- increased number of receptors
- increased NT activity
Why are dendritic spines important for depression?
Hotspots for postsynaptic receptors
How are amines removed from the synapse and degraded?
- MAO breaks it down at the synapse or shortly after uptake
- renders dopamine inert
MAO favors this
How is bipolar similar to and different from depression?
Bipolar has all the things that go wrong with depression, but there's also an added GABA imbalance (or any other inhibitory NT)
Types of Bipolar disorder
- deep depression
- very high mania
- have depression
- mania is less severe than type I
What contributes to psychosis?
- hyperactivity of dopamine
- insufficiency of GABA at modulating glutaminergic activity in the limbic system
What is the most common type of psychosis?
How is schizophrenia different from depression and bipolar disorder (and other mood disorders)?
- does not cycle like depression/bipolar
- full recovery from schizophrenia is unlikely