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Flashcards in Study Guide 8 Deck (29)
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1

Predisposition to psychiatric disorders (short and long lived aspects)

- genetic/familial
- environmental
- psychosocial
- biological
- medical
- hormonal

2

Medical impact on predisposition to psychiatric disorders

Chronic illness

3

hormonal impact on predisposition to psychiatric disorders

SAD and PPD

4

SAD =

Seasonal affective disorder

5

PPD =

Postpartum depression

6

How does depression occur at the cellular level?

- decreased activity of postsynaptic receptor
- supersensitivity of the presynaptic autoreceptor
- decreased capacity for neurogenesis
- decreased activity of BDNF

7

What would cause decreased activity of the postsynaptic receptor?

- Decreased receptor presence
- decreased NT availability

8

With depression, what causes decreased capacity for neurogenesis?

High glucocorticoid levels = stress

9

BDNF =

Brain derived neurotropic factor

10

What is BDNF?

growth factor

11

BDNF activates neurogenesis here (especially)

Hippocampus (and other areas)

12

BDNF is a major player in:

- neurogenesis
- learning
- memory

13

How does BDNF influence creation of new neurons?

stimulates
- cell division
- migration of stem cells in the brain

14

BDNF is activated by

Exercise

15

What increases synthesis of BDNF?

Increased activity of neurotransmitters

16

What are the goals of using pharmacology to great depression/psychiatric disorders?

- inhibit breakdown of NT
- stimulate release of NT
- block reuptake of NT

17

What are the BIG THREE neurotransmitters implicated in psychiatric disorders?

- dopamine
- serotonin
- norepinephrine

18

How does tx with antidepressants change the brain?

- growth of dendritic spines
- increased number of receptors
- increased NT activity

19

Why are dendritic spines important for depression?

Hotspots for postsynaptic receptors

20

How are amines removed from the synapse and degraded?

- MAO breaks it down at the synapse or shortly after uptake
- renders dopamine inert

21

MAO favors this

Dopamine

22

How is bipolar similar to and different from depression?

Bipolar has all the things that go wrong with depression, but there's also an added GABA imbalance (or any other inhibitory NT)

23

Types of Bipolar disorder

Bipolar I
Bipolar II

24

Bipolar I

- deep depression
- very high mania

25

Bipolar II

- have depression
- mania is less severe than type I

26

What contributes to psychosis?

- hyperactivity of dopamine
- insufficiency of GABA at modulating glutaminergic activity in the limbic system

27

What is the most common type of psychosis?

Schizophrenia

28

How is schizophrenia different from depression and bipolar disorder (and other mood disorders)?

- does not cycle like depression/bipolar
- full recovery from schizophrenia is unlikely

29

What is the DO NOT MISS list?

- major depression
- suicide risk
- femoral head and neck fx
- cauda equina
- cervical myelopathy
- abdominal aortic aneurysm
- DVT
- PE
- atypical MI

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