9.12 Pharmacology 2 Flashcards Preview

8501 Clin Med > 9.12 Pharmacology 2 > Flashcards

Flashcards in 9.12 Pharmacology 2 Deck (16):
1

Easiest way to bring plasma concentrations to a specific level and maintain it there

via IV (can control it better this way)

2

What causes greater plasma concentrations of a medication?

a larger dose

3

What type of dosing results in fewer peaks and valleys?

- smaller
- more frequent

4

Most serious problem with drug interactions

biotransformation -

delaying metabolism may allow drug to exert effect for prolonged period, resulting in toxic effect

5

Aspirin (ASA) and methotrexate are both used to treat

rheumatoid arthritis

6

How do ASA and methotrexate act?

- ASA displaces methotrexate on binding site of plasma proteins
- causes unbound methotrexate to circulate in the blood » increases toxicity

7

Primary tx of RA

methotrexate

8

How can drugs interact?

- can alter effects and metabolism
- can improve with greater cumulative effect than a single drug
- can cause toxicity

***must monitor pt's meds***

9

What factors cause variations in drug response and metabolism?

- genetics
- disease
- drug interactions
- age
- sex
- other

10

How do genetics impact drug response and metabolism?

variations in genes that control protein synthesis

11

How does disease impact drug response and metabolism?

structural or functional damage to organs and tissues

12

How do drug interactions impact drug response and metabolism?

- additive effects
- cancel each other out
- toxicity

13

How does age impact drug response and metabolism? (elderly)

- elderly don't metabolize drugs as quickly
- age-related changes in organs affect pharmacokinetics and pharmacodynamics

14

How does age impact drug response and metabolism? (pediatrics)

may have problems due to

- immature liver and kidney function
- differences in membrane function
- regional blood flow
- regional body comp

15

How does sex impact drug response and metabolism?

- men and women absorb, distribute, and metabolize drugs differently
- hormonal differences
- GI function and enzyme activity may differ

16

What are some of the other factors that account for variations in drug response and metabolism?

- environmental
- occupational hazards
- cigarette smok
- ETOH
- burns
- SCI level of injury
- impaired drug clearance

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