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Flashcards in Study Guide 1 Deck (26):
1

What is often used for chronic pain when conservative tx doesn't work?

Antidepressants

2

SSRIs are used to regulate:

- mood
- depression

3

SSRIs are good for these pts

People who have slightly decreased serotonin levels

4

This SSRI is often used for chronic pain

Paroxetine (Paxil)

5

What does SNRI stand for?

Serotonin-Norepinephrine Reuptake Inhibitors

6

What are SNRIs used for?

Depression

7

Off-label uses for SNRIs

- chronic pain
- OA
- peripheral neuropathies
- fibromyalgia

8

Why are SSRIs/SNRIs used to treat pain? (How does this work physiologically?)

Restores serotonin influence in descending pathways that inhibit pain

9

What are tricyclics used for?

Depression

10

When are tricyclics used over SSRI/SNRI?

Only for pts who fail with SSRI/SNRI

11

Tricyclics can also be used to treat this

Pain

12

MAOI

Monoamine Oxidase Inhibitors

13

What class of drugs are MAOIs?

Antidepressants

14

Lithium is used to treat ________

Bipolar disorder

15

This class of drug is used to treat schizophrenia

Antipsychotics

16

How do SSRIs work?

block reuptake of serotonin into the presynaptic terminal

17

How does increased serotonin in the presynaptic terminal create change?

- remains in cleft longer
- increases receptor sensitivity
- increases neuronal growth/function

18

How do SNRIs act physiologically?

- decrease serotonin and norepinephrine reuptake
- same mechanism as SSRI

19

SNRIs decrease serotonin and norepinephrine reuptake without affecting these:

Dopamine synapses

20

What do tricyclics block?

Reuptake of amine neurotransmitters into the presynaptic terminal

21

What is an important thing to note about the mechanism of action of tricyclics?

- nonselective
- block serotonin, norepinephrine, and dopamine!

22

What is MAO (monoamine oxidase)?

- enzyme that destroys released NTs
- hits a lot of targets

23

How do MAOIs work?

inhibit MAO to allow more NT to stay in the synaptic cleft

24

MAOIs favor _______

Dopamine

25

Mechanism of action: lithium

Multiple possible pathways of interaction
- may prevent neuronal degeneration and sustain function
- may be neuro protective

26

Mechanism of action: antipsychotics

Traditional meds for this are dopamine antagonists

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