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8501 Clin Med > Ciccone Doc 3 > Flashcards

Flashcards in Ciccone Doc 3 Deck (17)
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1

Drug types that inhibit bacterial protein synthesis

- Erythromycin
- Tetracycline
- Chloromycetin
- Clindamycin
- Ketek

2

Specificity of drugs that inhibit protein synthesis

very broad spectrum
- affects gram +/-
- no specificity

3

Why are drugs that inhibit bacterial protein synthesis not used with children?

- nephrotoxicity
- ototoxicity

4

Erythromycin useful in

airway infections

5

When a pt is on erythromycin, need to monitor

liver function

6

Erythromycin hits these types of bacteria

Gram +/-

7

Overall effects tetracycline may have

- anti-inflammatory
- neuroprotective
- immunomodulation

8

Tetracyclines are being investigated for use in

- Parkinson's
- cancer
- dermatological condition (rosacea)
- CVD

9

With tetracycline, you should look out for

- photosensitivity
- interference with osteoblast/clasts in bone remodeling (useful in adults)

10

Tetracycline causes permanent discoloration of:

- teeth (kids)
- bone
- skin

11

When is chloromycetin used?

reserved for non-responsive infections

12

What may chloromycetin lead to?

aplastic anemia

13

This drug predisposes a pt to getting C-diff

Clindamycin

**black box warning for it!**

14

What type of drug is Ketek?

ketolide antibacterials
(new class of drugs)

15

Ketek is a derivative of

Erythromycin

16

Ketek may be useful in

bacterial resistance

17

Ketek is toxic to:

hepatotoxic due to first pass effect

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