Immunodeficiency 1 Flashcards Preview

8501 Clin Med > Immunodeficiency 1 > Flashcards

Flashcards in Immunodeficiency 1 Deck (17):
1

Immunodeficiency occurs as a result of:

result of either a primary or secondary disorder

2

A primary immunodeficiency disorder occurs from a defect involving:

- T cells
- B cells
- lymphoid tissues

3

A secondary immunodeficiency disorder occurs because of:

Underlying factor or disease that suppresses or blocks the immune response

4

Iatrogenic immunodeficiency is induced by one of these:

- immunosuppressive drugs
- radiation therapy
- splenectomy

5

What are immunosuppressive drugs that can cause iatrogenic immunodeficiency?

- cytotoxic drugs
- corticosteroids
- cyclosporine
- anti-lymphocyte serum

6

How much of the immune tissue lies in the gut?

2/3

7

Major central organs of the immune system

- thymus gland
- bone marrow

8

Major peripheral organs of the immune system

- tonsils
- lymph nodes
- spleen
- interstitial lymphoid tissue

9

What is a major site of interstitial lymphoid tissue?

Peyers patches

10

What are the effects of radiation therapy on the immune system?

- cytotoxic to lymphocytes
- profound lymphopenia

11

What is total nodal irradiation?

radiation of all major lymph node areas

12

What is total nodal irradiation used for?

Hodgkins lymphoma

13

What is Hodgkins lymphoma?

cancer of the lymphatic system

14

Total nodal irradiation has been investigated for use in these:

- severe RA
- lupus nephritis
- kidney transplant rejection

15

What are the consequences of immunodeficiency?

- increased risk of developing infection
- Normal mechanical defense mechanisms are affected (respiratory, GI, etc.)

16

Normal flora in immunodeficient people

Body flora that are typically harmless become pathologic/source of infection

17

What are immunodeficient people more susceptible to than others?

common everyday and exotic infectious organisms

Decks in 8501 Clin Med Class (102):