Flashcards in Viruses/Fungi 6 Deck (22):
1
lyme disease comes from this
tick-borne spirochete bacteria
2
How many stages of lyme disease?
4
3
Lyme disease: stage 1
flu-like symptoms
4
Lyme disease: stage 2
disseminated infection that may include:
- aseptic meningitis
- stiff neck
- mentation problems
- cranial neuropathies
- radiculopathies
5
Lyme disease: stage 3
late persistent infections
6
What happens if lyme disease is untreated?
6% of those infected can have erosions or permanent joint abnormalities
7
Lyme disease: stage 4
post-infection syndromes that resemble fibromyalgia or chronic fatigue syndrome
8
What is CD4+?
T-helper lymphocytes
9
This type of HIV is less likely to progress to AIDS
HIV-2
10
What is HIV regarded as (disorder type)
degenerative neuromuscular
11
When CD4+ gets below ____, body can't combat what it needs to and you get full blown AIDS
100
12
HIV drugs: what do they target?
- viral replication
- different points of HIV proliferation
*often inhibit enzymes
13
Types of HIV drugs
- nucleoside reverse transcriptase inhibitors (NRTIs)
- nonnucleoside reverse transcriptase inhibitors (NNRTIs)
- HIV protease inhibitors
- HIV entry inhibitors
- integrase inhibitors
14
example of an NRTI
Zidovudine (retrovir)
15
What does retrovir do?
inhibitors reverse transcriptase enzyme that synthesizes DNA from RNA
16
What do NNRTIs do?
inhibit the active site of an enzyme
17
Which drugs are HIV protease inhibitors?
-avir drugs
18
What are integrase inhibitors?
prevent HIV from integrating genetic code into host DNA
19
primary drug strategy for HIV
HAART
20
HAART =
high active antiretroviral therapy
combined approach of multiple drugs
21
What is the problem with HAART?
- no drug can kill HIV
- can't reduce viral load in 20% of patients
- long term compliance
- viral resistance
22