Viruses/Fungi 6 Flashcards Preview

8501 Clin Med > Viruses/Fungi 6 > Flashcards

Flashcards in Viruses/Fungi 6 Deck (22):
1

lyme disease comes from this

tick-borne spirochete bacteria

2

How many stages of lyme disease?

4

3

Lyme disease: stage 1

flu-like symptoms

4

Lyme disease: stage 2

disseminated infection that may include:

- aseptic meningitis
- stiff neck
- mentation problems
- cranial neuropathies
- radiculopathies

5

Lyme disease: stage 3

late persistent infections

6

What happens if lyme disease is untreated?

6% of those infected can have erosions or permanent joint abnormalities

7

Lyme disease: stage 4

post-infection syndromes that resemble fibromyalgia or chronic fatigue syndrome

8

What is CD4+?

T-helper lymphocytes

9

This type of HIV is less likely to progress to AIDS

HIV-2

10

What is HIV regarded as (disorder type)

degenerative neuromuscular

11

When CD4+ gets below ____, body can't combat what it needs to and you get full blown AIDS

100

12

HIV drugs: what do they target?

- viral replication
- different points of HIV proliferation

*often inhibit enzymes

13

Types of HIV drugs

- nucleoside reverse transcriptase inhibitors (NRTIs)
- nonnucleoside reverse transcriptase inhibitors (NNRTIs)
- HIV protease inhibitors
- HIV entry inhibitors
- integrase inhibitors

14

example of an NRTI

Zidovudine (retrovir)

15

What does retrovir do?

inhibitors reverse transcriptase enzyme that synthesizes DNA from RNA

16

What do NNRTIs do?

inhibit the active site of an enzyme

17

Which drugs are HIV protease inhibitors?

-avir drugs

18

What are integrase inhibitors?

prevent HIV from integrating genetic code into host DNA

19

primary drug strategy for HIV

HAART

20

HAART =

high active antiretroviral therapy

combined approach of multiple drugs

21

What is the problem with HAART?

- no drug can kill HIV
- can't reduce viral load in 20% of patients
- long term compliance
- viral resistance

22

What must happen with HAART to maintain a functional immune system?

promotion of t-lymphocyte survival

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