Flashcards in Viruses/Fungi 6 Deck (22):
lyme disease comes from this
tick-borne spirochete bacteria
How many stages of lyme disease?
Lyme disease: stage 1
Lyme disease: stage 2
disseminated infection that may include:
- aseptic meningitis
- stiff neck
- mentation problems
- cranial neuropathies
Lyme disease: stage 3
late persistent infections
What happens if lyme disease is untreated?
6% of those infected can have erosions or permanent joint abnormalities
Lyme disease: stage 4
post-infection syndromes that resemble fibromyalgia or chronic fatigue syndrome
What is CD4+?
This type of HIV is less likely to progress to AIDS
What is HIV regarded as (disorder type)
When CD4+ gets below ____, body can't combat what it needs to and you get full blown AIDS
HIV drugs: what do they target?
- viral replication
- different points of HIV proliferation
*often inhibit enzymes
Types of HIV drugs
- nucleoside reverse transcriptase inhibitors (NRTIs)
- nonnucleoside reverse transcriptase inhibitors (NNRTIs)
- HIV protease inhibitors
- HIV entry inhibitors
- integrase inhibitors
example of an NRTI
What does retrovir do?
inhibitors reverse transcriptase enzyme that synthesizes DNA from RNA
What do NNRTIs do?
inhibit the active site of an enzyme
Which drugs are HIV protease inhibitors?
What are integrase inhibitors?
prevent HIV from integrating genetic code into host DNA
primary drug strategy for HIV
high active antiretroviral therapy
combined approach of multiple drugs
What is the problem with HAART?
- no drug can kill HIV
- can't reduce viral load in 20% of patients
- long term compliance
- viral resistance