MS 5 Flashcards
(29 cards)
Medications for MS do this:
- modify disease course
- treat attacks
- manage symptoms
How many disease-modifying agents approved by the FDA?
14
Types of disease-modifying agents that can be used to treat MS
- self-injectables
- oral
- IV
How many self-injectables are available to treat MS?
8
How many oral drugs are available to treat MS?
3
How many IV drugs are available to treat MS?
3
Drug type: Natalizumab (Tysabri)
IV
Drug type: Teriflunomide (Aubagio)
Oral
Drug type: Fingolimod (Gilenya)
Oral
Drug type: Interferon beta 1-a (Avonex and Rebif)
Self-injectable
Drug type: Interferon beta 1-b (Betaseron and Extavia)
Self-injectable
Drug type: Daclizumab (Zinbryta)
Self-injectable
Drug type: Dimethyl fumarate (Tecfidera)
Oral
Drug type: Mitoxantrone (Novantrone)
IV
Drug type: Glatiramer acetate (Copaxone and Glatopa)
Self-injectable
Drug type: Peginterferon beta 1-a (Plegridy)
Self-injectable
Drug type: Alemtuzumab (Lemtrada)
IV
Why is early tx so early with MS?
Neuroinflammation and neurodegeneration occur early in the disease course
Individuals with first clinical event with MRI findings consistent with MS have:
high probability of further disease activity
Significance of early disease activity
Likely impacts long-term disability
What types of cognitive/emotional changes occur early on in MS?
- cognitive changes
- depression
- fatigue
Impact of tx following first clinical event
- Delay conversion to definite MS
- Reduce brain atrophy and disability worsening
Why does tx need to be ongoing for MS?
- once tx is initiated, it needs to be ongoing for benefits to continue
- cessation negatively impacts outcomes
- relapse rates can return to baseline if tx is interrupted
What happens to FSS and EDSS scores if tx is stopped and relapse rates return to baseline?
both increase
