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8501 Clin Med > Pharm 5 > Flashcards

Flashcards in Pharm 5 Deck (23)
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1

What are the classes of sedative-hypnotic drugs?

- benzodiazepines
- non-benzodiazepines (barbiturates)
- non-benzodiazepines (sedative hypnotics)
- other nonbenzodiazepines

2

Sedative hypnotic drugs:

Benzodiazepines

- Halcion
- Restoril

3

Sedative hypnotic drugs:

Non-benzodiazepines (barbiturates)

- Luminal/phenobarbital
- Nembutal/pentobarbital
- Seconal/secobarbital

4

Sedative hypnotic drugs:

Non-benzodiazepines sedative hypnotics

- Ambien
- Sonata
- Lunesta
- Rozerem

5

Sedative hypnotic drugs:

Other non-benzodiazepines

Tylenol
Advil PM
Benadryl
Nyquil

Etc.

6

Anti-anxiety drugs: classes

- benzodiazepines
- antidepressants

7

Anti-anxiety drugs:

Benzodiazepines

- Valium
- Xanax
- Ativan

8

Anti-anxiety drugs:

Antidepressants

- Cymbalta
- Lexapro
- Paxil
- Zoloft
- Effexor
- XR

9

Which drug classes are used as anti-seizure drugs?

- Barbiturates
- Benzodiazepines
- Hydantoins
- Iminostilbenes
- Succinimides
- Valproates

10

Which benzodiazepines are helpful for acute status epilepticus (not long term)?

- Valium
- Ativan

11

Anti-seizure drugs:

Hydantoins - off-label use

Neuropathic pain

12

Anti-seizure drugs:

Hydantoins - adverse effects

- cerebellar signs
- gingival hyperplasia

13

Anti-seizure drugs: How do iminostilbenes work?

By slowing recovery of Na+ channels from firing too rapidly

14

Anti-seizure drugs:

Iminostilbenes - adverse effects

issues with salt imbalances

- water retention
- antidiuretic hormone release
- cardiac arrhythmias
- CHF

15

Anti-seizure drugs: example of a succinimide drug

Zarontin

16

In addition to seizures, valproate are also used to treat

BP

17

This drug class is used to treat absence seizures

Succinimides (Zarontin)

18

What are 2nd generation anti-seizure drugs?

Used as an add-on to first gen drugs ("specialty drugs")

19

Which are the two second generation anti-seizure drugs?

- gabapentin
- lyrica

20

Adverse effects of gabapentin (and other anti-anxiety drugs)

- sedation
- fatigue
- dizziness
- ataxia

21

Adverse effects of lyrica

- dizziness
- drowsiness
- peripheral edema

22

How does Lyrica cause peripheral edema?

Inhibition of Ca2+ channels

23

What is the 2nd gen anti-seizure drug, Lyrica, used for?

Chronic pain
- fibromyalgia
- diabetic peripheral neuropathy
- post-herpetic neuralgia

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