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Flashcards in Study Guide 7 Deck (26)
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1

Protein implicated in PD

N/A

2

Region of the brain most affected in PD

BG in cerebrum and midbrain

3

Which cell types are targeted first in PD?

Dopaminergic

4

Structural changes in brain with PD

None, minus cell death in BG

5

Cell death in the BG with PD - specific areas affected

- substantia nigra compacta
- PPN

6

Levodopa side effects

- N/V
- arrhythmias
- OH
- dyskinesia
- behavioral changes

7

What is it called when PD medication wears off before the next dose?

End of dose akinesia

8

What helps with end of dose akinesia?

Twice a day scheduling

9

What is the phenomenon with PD where meds fluctuate in effectiveness and you get freezing?

On/off phenomenon

10

What can be done to combat loss of effectiveness of PD drugs?

Take a drug holiday

11

Proteins implicated in AD

- amyloid plaques (accumulate extracellularly)
- tau (accumulate intracellularly)

12

Area of the brain targeted first in AD

Hippocampus

13

What results from AD targeting the hippocampus first? (S/s)

- memory loss
- cognition loss
- executive function loss

14

What neuronal cell types are targeted first with AD?

Cholinergic

15

What structural changes occur in the brain with AD?

Widespread inflammation and death of cholinergic cells in the limbic system

16

Medication to treat AD inhibit this

ACH breakdown

17

General categories of treatment for AD

- behavioral management
- medication
- hormone replacement
- ginkgo biloba

18

Caution with ginkgo

Use cautiously in pts at risk for bleeding or on blood thinners

19

Pick's dz is a type of

Frontotemporal dementia

20

Potential cause of Pick's dz

Misfolded proteins (ubiquitin system)

21

What structural changes can occur in the brain with frontotemporal dementia?

Accumulation of misfolded proteins

22

What areas of the brain are targeted first with Lewy body dementia?

- BG
- brainstem

23

Which neuronal cell types are targeted first with Lewy body dementia?

Dopaminergic

24

What structural changes can occur in the brain with Lewy body dementia?

Marked inflammation and neuronal death in the BG and brainstem

25

General tx for Lewy body dementia

None discussed in class

26

Protein implicated with CTE

Tau

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