Flashcards in 9.21 Injury, Inflammation, Healing 5 Deck (20)
local factors affecting the healing process
- type, size, location of injury
- vascular supply
- external forces
First local factor affecting the healing process that you should look at
How might modalities play a role in the healing process?
External force: Is it contributing to or detracting from the healing process?
Systemic factors affecting the healing process
What happens during hemostasis and degeneration?
- coagulation to stop bleeding
- formation of hematoma
- necrosis of dead cells
- beginning to repair tissue defect
function of inflammation
When does inflammation begin?
when the blood clot forms
When does the proliferation and migration phase begin?
within 2 days of injury
What happens in the proliferation/migration phase?
endothelial cells proliferate and migrate to cover and vascularize the wound
What happens to scar tissue during the remodeling and maturation phase?
reduced and remodeled, possibly over many months
Platelets bind to _____ and release _____
What do fibrin and fibronectin limit?
- fluid drainage
How do fibrin and fibronectin make sure cells have something to grow onto?
by laying a "net" over the sound
How do fibrin and fibronectin help with clot formation?
by giving the platelets something to hang onto
The hemostatic response is also an important component of this response
When does acute inflammation subside?
once the injurious agent is removed
Acute inflammation follows this
Chronic inflammation is the result of
- extensive necrosis OR
- inability of parenchymal cells to regenerate
This is needed for clotting