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8501 Clin Med > Pharm 1 > Flashcards

Flashcards in Pharm 1 Deck (22):
1

What are the categories of sedative-hypnotic drugs?

- benzodiazepines
- non-benzodiazepines

2

How do benzodiazepines help pts relax?

by boosting GABA

3

Two big issues with benzos

- potentially addicting
- residual effects the next day

4

benzodiazepines and addiction

tolerance builds to dependence

5

What residual effects are often seen with benzodiazepines the next day?

- drowsiness
- decreased motor performance

6

Name 2 examples of benzos

- Trizolam (Halcion)
- Temazepam (Restoril)

7

Barbiturates are (categories)

- sedative-hypnotic drugs
- non-benzodiazepines

8

What is the sedative-hypnotic component of barbiturates?

barbituric acid

9

barbiturates: MOA

- unclear
- can produce general anesthesia and neuronal excitability in brain and SC

10

Why are barbiturates potentially very dangerous?

- very small TI
- just 10x therapeutic dose can be fatal
- very addicting

11

Name 3 examples of barbiturates

- Phenobarbital (Luminal)
- Pentobarbital (Nembutal)
- Secobarbital (Seconal)

12

How are sedative-hyponotics (non-benzos) and benzos similar/different (binding)?

- both bind to GABA
- chemically different from benzos

13

Why might sedative-hypnotics (non-benzos)

- less risk
- shorter duration
- less "hangover" next day

14

What are sedative-hypnotic drugs often prescribed as?

sleep aids

15

What are 3 examples of non-benzodiazepines commonly prescribed for sleep?

- Ambien
- Sonata
- Lunesta

16

Which non-benzodiazepine sedative-hypnotic drug is similar to melatonin?

Ramelteon (Rozerem)

17

Why might Rozerem be chosen over melatonin for sleep?

- structure and function are similar to melatonin
- less risk
- better for long term insomnia

18

Which non-benzo is often associated with sleep-walking/driving

Ambien

19

In the category of "other" non-benzodiazepines, how do they promote relaxation and sleep?

via CNS depression

20

examples of some of the "other" non-benzodiazepines

- ETOH
- antihistamines (OTC "sleep aids")

21

What other types of drugs can be used in limited situations to promote sleep?

- antidepressants
- anticonvulsants
- opioid analgesics

22

What are some adverse effects of sedative-hypnotics?

- anterograde amnesia
- sedative "hangover" in cognitive and motor function
- tolerance and physical dependence
- sleep-walking/driving

Decks in 8501 Clin Med Class (102):