Flashcards in 9.21 Injury, Inflammation, Healing 10 Deck (27)
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1
keloid
beyond boundaries of injury
2
tx for keloids
- surgical
- poor outcomes
3
hypertrophic scars
- synthesis greater than lysis
- commonly seen with burn patients
4
tx for hypertrophic scars
- pressure garments
- Do a great job of flattening the skin and normalizing as much as possible
5
If joints are involved, contractures are called
arthrofibrosis
6
contractures
- can be muscle, tendon, skin, etc
- joint capsule and capsular ligaments
- arthrofibrosis
7
specific tissue healing:
lungs: regeneration vs. repair
- regeneration can occur if basement membrane is intact
- repair if damage is extensive
8
specific tissue healing: cartilate (both types)
- poor blood supply
- poor healing
9
specific tissue healing:
bone
- inflammation
- soft callus
- hard callus
- regeneration and remodeling
10
bone healing: hard callus formation occurs when?
3 weeks - 4 months
11
bone healing: regeneration and remodeling time frame
months to years
12
specific tissue healing:
skeletal muscle
- regeneration can occur
- scarring is likely
- no proliferation
- myositis ossificans
13
specific tissue healing:
tendons and ligaments (process)
- 72 hour inflammation
- collagen synthesis (2 weeks)
- tendons no AROM x 3 weeks
- tendons no max force x 8 weeks
- PROM indicated for both tissues within limits
14
specific tissue healing:
others
- digestive tract
- nerves
- synovial membranes
- discs
etc.
15
inflammatory and immune systems of neonates
transiently depressed inflammatory and immune systems
- takes time for everything to kick into gear after birth
16
How long do neonates need to develop immune/inflammatory systems?
1 month to 6 weeks
17
neonates: neutrophils
neutrophils not capable of efficient chemotaxis
**first line of defense down
18
In addition to inflammatory/immune system and neutrophils, what else are neonates deficient in?
- complement system
- oxidative and bacterial responses
can develop overwhelming sepsis!!!
19
How might capillary fragility occur?
- repeated sun exposure
- age over 60
20
problems with older adults
- impaired fx of innate immune cells (phagocytes)
- impaired inflammation
- chronic medication intake
- diminished healing response
- infections and chronic inflammation
21
older adults: impaired inflammation is likely a result of
chronic illness (diabetes, cardiovascular disease, etc.)
22
older adults: chronic medication intake does this to the inflammatory response
decreases
23
older adults: Why is healing response diminished?
skin's loss of regenerative ability
24
These are more common in older adults
- infection
- chronic inflammation
25
Two examples of crappy healing
- heterotopic ossification
- myositis ossificans
26
group that commonly gets heterotopic ossification and myositis ossificans
SCI pts
27
