9.21 Injury, Inflammation, Healing 10 Flashcards Preview

8501 Clin Med > 9.21 Injury, Inflammation, Healing 10 > Flashcards

Flashcards in 9.21 Injury, Inflammation, Healing 10 Deck (27)
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1

keloid

beyond boundaries of injury

2

tx for keloids

- surgical
- poor outcomes

3

hypertrophic scars

- synthesis greater than lysis
- commonly seen with burn patients

4

tx for hypertrophic scars

- pressure garments
- Do a great job of flattening the skin and normalizing as much as possible

5

If joints are involved, contractures are called

arthrofibrosis

6

contractures

- can be muscle, tendon, skin, etc
- joint capsule and capsular ligaments
- arthrofibrosis

7

specific tissue healing:

lungs: regeneration vs. repair

- regeneration can occur if basement membrane is intact
- repair if damage is extensive

8

specific tissue healing: cartilate (both types)

- poor blood supply
- poor healing

9

specific tissue healing:

bone

- inflammation
- soft callus
- hard callus
- regeneration and remodeling

10

bone healing: hard callus formation occurs when?

3 weeks - 4 months

11

bone healing: regeneration and remodeling time frame

months to years

12

specific tissue healing:

skeletal muscle

- regeneration can occur
- scarring is likely

- no proliferation
- myositis ossificans

13

specific tissue healing:

tendons and ligaments (process)

- 72 hour inflammation
- collagen synthesis (2 weeks)
- tendons no AROM x 3 weeks
- tendons no max force x 8 weeks
- PROM indicated for both tissues within limits

14

specific tissue healing:

others

- digestive tract
- nerves
- synovial membranes
- discs

etc.

15

inflammatory and immune systems of neonates

transiently depressed inflammatory and immune systems

- takes time for everything to kick into gear after birth

16

How long do neonates need to develop immune/inflammatory systems?

1 month to 6 weeks

17

neonates: neutrophils

neutrophils not capable of efficient chemotaxis

**first line of defense down

18

In addition to inflammatory/immune system and neutrophils, what else are neonates deficient in?

- complement system
- oxidative and bacterial responses

can develop overwhelming sepsis!!!

19

How might capillary fragility occur?

- repeated sun exposure
- age over 60

20

problems with older adults

- impaired fx of innate immune cells (phagocytes)
- impaired inflammation
- chronic medication intake
- diminished healing response
- infections and chronic inflammation

21

older adults: impaired inflammation is likely a result of

chronic illness (diabetes, cardiovascular disease, etc.)

22

older adults: chronic medication intake does this to the inflammatory response

decreases

23

older adults: Why is healing response diminished?

skin's loss of regenerative ability

24

These are more common in older adults

- infection
- chronic inflammation

25

Two examples of crappy healing

- heterotopic ossification
- myositis ossificans

26

group that commonly gets heterotopic ossification and myositis ossificans

SCI pts

27

Dealing with myositis ossificans

- gradual stiffening
- swelling, warmth, redness
- progressive loss of motion

- generally involves surgical removal

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