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Flashcards in Hematology Deck (35):
1

what does the buffy coat contain?

leukocytes and platelets

2

what is the function of blood?

deliver oxygen and nutrients to cells
regulation body temperature
transport wastes away from cells
maintain pH
maintain blood volume

3

what does plasma contain?

mostly water, albumin, fibrinogen, globulins (antibodies), electrolytes, nutrients (glucose, amino acids), gases (oxygen, CO2), waste products

4

where are most of the plasma proteins manufactured?

liver

5

what is the most abundant plasma protein?

albumin

6

what is a major function of albumin?

regulates water movement between interstitial space and osmotic pressure of blood

7

what is serum?

plasma minus coagulation factors

8

what is the precursor of all blood cells?

pluripotent stem cell (hemocytoblast)

9

what does RBC do with its nucleus?

makes hemoglobin

10

what are platelets?

cell fragments of megakaryocyte

11

what is erythropoeitin?

increase rate of production of RBC
excreted by the kidney

12

what suppresses bone marrow?

chemotherapy

13

what are cytokines?

cell encouraging factors-stimulate progenitor cells in the bone marrow

14

why is RBC biconcave?

increases surface area
felxibility

15

what kind of metabolism do RBC use?

anaerobic (does not use the oxygen that it carries)

16

what is Rouleaux?

how RBC go single file through capillaries

17

what causes higher viscosity?

increased red cells

18

what is spectrin?

protein in RBC that helps maintain shape

19

where does oxygen bind to hemoglobin?

iron group

20

what percentage of CO2 is attached to the hemoglobin?

20%

21

where is the rest of CO2 transported as in the blood?

bicarb

22

how do CO poisoning pts present?

ruby red skin and buccal mucosa

23

what is the role of NO?

vasodilation (more oxygen can reach the tissues)

24

where is EPO synthesized?

kidney

25

what is the stimulus to release more EPO?

hypoxia, decreased RBC or Hb or available O2

26

how does testosterone control blood volume?

increases EPO production by kidney

27

where is iron stored?

liver /ferritin

28

what is a cytochromes?

liver enzyme systems

29

what kind of anemia will B12 and folate deficiencies cause?

macrocytic anemia

30

what is intrinsic factor?

made in the stomach by the parietal cell that allows for B12 to be absorbed

31

what is stercobilin?

most common breakdown product of bilirubin

32

what toxic neurological problem results from high levels of bilirubin?

kernicterus-irreversible involuntary movement

33

what is autosplenectomy?

sickle cell patients that over time put scar tissue on spleen and it appears as if there is no spleen

34

what is polycythemia vera?

bone marrow cancer that creates too many cells

35

what is secondary polycythemia?

smokers or ppl at high altitude
kidney detects hypoxia and makes more EPO

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