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Flashcards in CSF Analysis Deck (24):
1

autoimmune disease of the CNS

ALS
SLE
MS (demyelinating disorders)
Neurosyphilis

2

how do you obtain CSF?

lumbar puncture from subarachnoid space

3

where is the CSF produced?

choroid plexus of the ventricles

4

what are the roles of CSF?

transports nutrients
clears metabolic waste

5

what could blood in the tap indicate?

subarachnoid hemorrhage will not clot
traumatic tap will clot

6

what could cloudy CSF mean?

presence of WBC or protein

7

what could xanthochromia of the CSF mean?

yellow tinge
hyperbilirubinemia
hypercarotenemia
melanoma

8

elevated PMNs means

bacterial meningitis or cerebral abscess

9

what 4 tubes do you send in a CSF analysis?

culture
cell count, cytology
pH, protein, glucose, chloride
serology

10

common bacterial meningitis causers

H. influenzae
neisseria meningitis
S. pneumonia

11

common viral meningitis causers

herpes simplex
coxsackiervirus
echovirus
infectious mono

12

should protein be in CSF?

no, BBB should not allow it to cross
some disease can alter the permeability and allow protein to leak into the CSF

13

why is glucose important to the brain?

brain doesn't produce or store its own glucose

14

how do bacteria, inflammatory cells, and tumors impact glucose in CSF?

decreased

15

how do you test CSF glucose?

compare to serum glucose (drawn prior to LP)
should be >60% of serum

16

how will bacteria and fungal infection impact lactic acid in CSF?

increased
(indicates decreased oxygenation of the brain-anaerobic metabolism)

16

which tests identify syphilis?

Wasserman
Venereal Disease Research Lab test
Fluorescent Treponamal antibody (most spec and sens)

17

how is chloride level different in the CSF?

it is higher

18

what type of white blood cell is normally in the CSF?

lymphocyte mostly

19

what would presence of mononuclear leukocyte indicate?

viral
TB
encephalitis

20

how will infection or TB affect chloride levels?

decrease

21

how would infection or inflammation impact LD levels?

increase (comes from WBC that are fighting bacteria)

22

what level might be low when lactic acid level is high?

glucose level

23

what other test is useful for the diagnosis of bacterial meningitis?

CRP of serum (sensitive)

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