White blood cells Flashcards Preview

Medicine > White blood cells > Flashcards

Flashcards in White blood cells Deck (36):
1

what is diapedises?

WBC moving from circulation to tissue

2

what binds together during diapedesis?

selectins with integrins

3

what is the range of leukocytosis?

>11,000 wbc

4

what is neutropenia?

low level of neutrophils, bad dog

5

what is defensin?

antibiotic like protein that is made by neutrophils

6

what is in the granules of eosinophils?

enzymes that match their function
-cannot digest bacteria

7

what is in the granules of the basophil?

histamine (allergies) and heparin (anticoagulant)

8

what WBC causes allergic symptoms?

basophil
-eosinophil tries to help control the reaction

9

what does mast cell do?

contains histamine and heparin
play a role in allergic phenomenon along with IgE
also produces tumor necrosis factor

10

what are the phases of the platelet cascade?

vascular spasm
platelet plug formation
coagulation (blood clotting)

11

what organ makes thrombopoeitin?

liver

12

what is the life span of platelet?

5-10 dys

13

what is normal platelet count?

150,000-400,000

14

what is the most common cause of thrombocytopenia?

autoimmune

15

what is a symptom of TTP?

petechiae and purpura

16

what is the lower threshold of platelets?

below 20,000

17

low platelets can also be linked to what?

malignancy

18

what is the role of thromboxane A2?

calls on more platelets to come to the injury

19

what is the role of PGI2? (prostacyclin)

controls the area around the hole so that platelets are locally aggregated

20

what hormone does platelet contain?

encourages healing of wound area

21

what two things cause platelets to become sticky?

ADP and thromboxane A2

22

which two things cause vasoconstriction?

serotonin and thromboxane A2

23

what happens to platelets when it becomes activated?

open their binding site for fibrinogen

24

what is NO's role in clotting?

inhibits platelet plug expansion around site of trauma

25

what is the mechanism of aspirin?

inhibits cyclooxygenase enzyme that generates protaglandins and thromboxanes
-low dose causes stead state decrease in platelet COX activity

26

how long is aspirin's affect?

life of the platelet (5-10 days)

27

what is Plavix used for?

reduce platelet aggregation

28

which ion is important for the coag cascade?

Ca2+

29

which clotting factors need vitamin K?

factors 2, 7, 9, 10

30

what produces vitamin k?

bacteria in the GI tract

31

who would have low levels of vitamin K?

ppl who have lipid malabsorption

32

what is plasmin?

enzyme that breaks down clot

33

what is one tissue plasminogen activator?

tpa used in suspected stroke

34

what systems limit the spread of the clot?

TF pathway inhibitor
pathway triggered by thrombin
antithrombin III

35

how does heparin work?

antithrombin III

36

how does TFPI work?

binds to factor VII to limit to damaged area

Decks in Medicine Class (146):