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Flashcards in HIV lecture 1 Deck (26):
1

what is the definition of HIV?

infection with retrovirus that depletes CD4+lymphocytes

2

what is the definitino of AIDS?

CD4 count < 200 OR any of the following

-thrush

-pneumocystis jirovechii pneumonia

-cryptococcal meningitis

-toxoplasmosis of CNS

-Karposi's sarcoma

(you won't get these unless you have HIV or impaired T-cell functioning)

3

what are the antiretroviral agents?

integrase inh

fusion inh

CCR5inh

NNRTI

NRTI

PI

4

who is at a greater risk for contraction HIV?

ppl with STDs (herpes, syphillis-lack skin barrier)

African Americans

5

HIV risk for uninfected pt depends on many factors, including...

infected persons viral load

recipients immune system

quantity of exposure

6

what two co-receptors does HIV bind to?

CCR5 and CXCR4

present on the surface of CD4+ t lymphocyte

7

what does reverse transcriptase do?

converts single stranded viral RNA into viral DNA

8

what does HIV do to "hide" in the cell?

HIV DNA enters host nucleus and the enzyme integrase hides HIV DNA within the host cell's own DNA

9

what is the provirus?

the integrated HIV DNA

-remains dormant for many years 

10

why is RNA polymerase not a target of therapy?

our normal cells need it

11

what does protease do?

helps in assembling HIV proteins

12

what are typical symptoms of acute HIV?

fever

fatigue

tender adenopathy

13

what will give the best index of suspicion of HIV?

HISTORY

14

when will antibody test be positive after exposure?

3 weeks to 6 months

15

diagnosis requires what as of 2012?

treatment

16

what should your screening test be?

sensitive

-very low false negative

-you don't want any positives to slip by

17

what is considered to be a diagnostic HIV test?

testing for HIV based on clinical signs or symptoms

18

what would be a targeted HIV test?

testing for HIV based on bieng part of a subpopulation that is at higher risk based on behavioral, clinical or demographic

19

what is opt-out HIV screening?

testing for HIV after notifying the pt that the test will be done, but would have to opt out to not be tested

20

what demographic comprises the "late testers"

younger, hetero, AA or hispanic, less educated

21

what is the normal CD4/CD8 ratio?

35%

CD4 of 500 would be 29%

CD4 of 200 would be 14%

22

what would be considered an undetectable level of viral load?

20-40 copies/mL

23

which gene is a/w life threatening problem with abacavir?

HLA-B5701

24

what type of vaccinations would you use for an HIV pt?

inactive kind

25

what extra vaccine would you give to HIV pts?

pneumococcal 13 and 23

26

what kind of HIV pts would receive Hep A and B vaccinations?

MSM

IVDU

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