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Flashcards in Adaptive Immunity Deck (29):
1

when does a lymphocyte complete maturation?

when ti becomes exposed to an antigen

2

what is humoral immunity?

B cell and antibody mediated

only functions on organisms OUTSIDE the cell

3

what is cellular immunity?

T cells that directly kill infected cells

4

what is clonal selection?

when a lymphocyte divides and differentiates in response to a specific antigen

5

where does clonal selection occur?

in secondary lymphatic tissue

6

what two characteristics do antigens have?

1. immunogenicity

2. reactivity

7

what are the strongest antigens?

proteins

8

what is a hapten?

is an incomplete antigen

has reactivity, but not immunogenicity

9

what is an epitope?

specific portion of the molecule that evokes an immune response

10

which cells do not have MHC 1?

RBC

11

which T cells deal with exogenous antigens?

helper T (CD4)

12

which T cells deal with endogenous antigens?

cytotoxic (CD8)

13

how is a T cell receptor different than an antibody?

has only 2 polypeptide chains instead of 4

14

what is anergy?

TCR bound to an MHC presenting complex with no costimulation

15

list the steps of T cell activation and cloning?

1. APC binds with TCR

2. CD 4 protein and cytokines costimulate to activate T cell

3. T cells are cloned into active cells and memory cells (mediated by interleukin 2)

16

what are TH2 cells?

regulatory cells that stimulate proliferation of the other T cells and B cells

17

which interleukin costimulates CD4 cells?

1

18

which interleukin costimulates CD8 cells?

2

19

in the humoral immune system, what is circulating?

antibodies

20

list the process of B cell activation

1. B cell takes in antigens and presents with a MHC II complex

2. T helper cells recognizes antigen and give costimulation to proliferate B cells

3. T cell secretes interleukin 2 that functions and co stimulator

4 B cells get cloned

21

how many antigen binding sites do most antibodies have?

2

22

what 4 functions do antibodies serve?

1. neutralization

2. agglutination

3. precipitation

4. complement (opsonization)

23

which complement proteins are responsible for opsonization?

C3b

24

which complement proteins are responsible for MAC?

C5-C9

25

which complement proteins are responsible for inflammation?

C3a, C5a

26

what is the classic complement pathway?

antibody binding with antigen (activates C1

27

what is the alternative pathway?

interaction with factors B, D and P whic activates C3

28

what is the lectin complement pathway?

lectins binding with carbohydrates on the microbe which activates c3

29

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