Flashcards in Liver Studies Deck (65)
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1
which test is used to identify hepatocellular disease?
ALT (found in cytosol of liver)
2
what does ALT stand for?
alanine aminotransferase
3
what are the normal ALT values?
4-36 IU/L
4
what are the interfering drugs for ALT?
PAMS PODP
phenothiazine, acetaminophen, methotrexate, statins, procainamide, OCP, dilatin, propoxyphene
5
myositis, pancreatitis, MI, infections mono and shock would produce what level of ALT/
mildly elevated
6
cirrhosis, cholestasis, hepatic tumor, hepatotoxic drug, obstructive jaundice, severe burns and muscle trauma would produce what level of ALT?
moderately elevate
7
hepatitis, hepatic necrosis and hepatic ischemia would produce what level of ALT/
significantly elevated
8
what does AST stand for?
aspartate aminotransferase (found in liver, heart, skeletal muscle, kidney, pancreas and RBC)
9
what are normal AST values?
0-35
10
how will AST levels change with injury?
elevates at 8hrs
peaks at 24-26 hrs
normal at 3-7 days
11
what drugs interfere with AST levels?
SAVE CODOIC
salicylates, antihypertensive, verapamil, E-mycin, cholinergics, OCP, digoxin, opiates, INH, coumadin
12
acute renal dz, beriberi, DKA, pregnancy would cause what levels of AST?
low
13
liver dz would cause what level of AST/
elevated
14
where is alkaline phosphatase found?
liver, bone, biliary tract
intestine, kidney, placenta, leukocytes
15
what are normal ALP levels?
30-120
16
what is ALP1 isoenzyme specific for?
liver origin
17
what is ALP2 isoenzyme specific for?
bone origin
18
hypophosphatemia, malnutrition, milk-alkali syndrome, pernicious anemia and scurvy would cause what level of ALP?
decreased
19
liver dz, normal pregnancy, normal bone growth, bone tumors, fractures, paget dz, and others would cause what levels of ALP?
increased
20
which drugs interfere with ALP levels?
too many
21
what is GGT?
gamma-glutamyl transpetidase
22
where is GGT found?
biliary tract, liver
kidney, spleen, heart, intestine, brain, prostate
23
what are normal GGT values?
8-38
very high in newborns
24
which is the most sensitive indicator of liver dz?
GGT level
-indicates heavy and chronic EtOH use
25
late pregnancy, clofibrate, OCP, will do what to GGT levels?
lower
26
EtOH, dilantin, liver dz, MI, pancreatic dz and phenobarbital will do what to GGT levels?
elevate
27
what is 5' NT?
5' nucleotidase
28
where is 5' NT found?
hepatocyte plamsa membrane
29
what is normal 5'NT value?
0-1.6
30
