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Flashcards in Liver Studies Deck (65)
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1

which test is used to identify hepatocellular disease?

ALT (found in cytosol of liver)

2

what does ALT stand for?

alanine aminotransferase

3

what are the normal ALT values?

4-36 IU/L

4

what are the interfering drugs for ALT?

PAMS PODP
phenothiazine, acetaminophen, methotrexate, statins, procainamide, OCP, dilatin, propoxyphene

5

myositis, pancreatitis, MI, infections mono and shock would produce what level of ALT/

mildly elevated

6

cirrhosis, cholestasis, hepatic tumor, hepatotoxic drug, obstructive jaundice, severe burns and muscle trauma would produce what level of ALT?

moderately elevate

7

hepatitis, hepatic necrosis and hepatic ischemia would produce what level of ALT/

significantly elevated

8

what does AST stand for?

aspartate aminotransferase (found in liver, heart, skeletal muscle, kidney, pancreas and RBC)

9

what are normal AST values?

0-35

10

how will AST levels change with injury?

elevates at 8hrs
peaks at 24-26 hrs
normal at 3-7 days

11

what drugs interfere with AST levels?

SAVE CODOIC
salicylates, antihypertensive, verapamil, E-mycin, cholinergics, OCP, digoxin, opiates, INH, coumadin

12

acute renal dz, beriberi, DKA, pregnancy would cause what levels of AST?

low

13

liver dz would cause what level of AST/

elevated

14

where is alkaline phosphatase found?

liver, bone, biliary tract
intestine, kidney, placenta, leukocytes

15

what are normal ALP levels?

30-120

16

what is ALP1 isoenzyme specific for?

liver origin

17

what is ALP2 isoenzyme specific for?

bone origin

18

hypophosphatemia, malnutrition, milk-alkali syndrome, pernicious anemia and scurvy would cause what level of ALP?

decreased

19

liver dz, normal pregnancy, normal bone growth, bone tumors, fractures, paget dz, and others would cause what levels of ALP?

increased

20

which drugs interfere with ALP levels?

too many

21

what is GGT?

gamma-glutamyl transpetidase

22

where is GGT found?

biliary tract, liver
kidney, spleen, heart, intestine, brain, prostate

23

what are normal GGT values?

8-38
very high in newborns

24

which is the most sensitive indicator of liver dz?

GGT level
-indicates heavy and chronic EtOH use

25

late pregnancy, clofibrate, OCP, will do what to GGT levels?

lower

26

EtOH, dilantin, liver dz, MI, pancreatic dz and phenobarbital will do what to GGT levels?

elevate

27

what is 5' NT?

5' nucleotidase

28

where is 5' NT found?

hepatocyte plamsa membrane

29

what is normal 5'NT value?

0-1.6

30

how is 5'NT used?

supports dx of obstructive hepatobiliary dz in pts with increased ALP

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