Flashcards in Liver Studies Deck (65)
which test is used to identify hepatocellular disease?
ALT (found in cytosol of liver)
what does ALT stand for?
what are the normal ALT values?
what are the interfering drugs for ALT?
phenothiazine, acetaminophen, methotrexate, statins, procainamide, OCP, dilatin, propoxyphene
myositis, pancreatitis, MI, infections mono and shock would produce what level of ALT/
cirrhosis, cholestasis, hepatic tumor, hepatotoxic drug, obstructive jaundice, severe burns and muscle trauma would produce what level of ALT?
hepatitis, hepatic necrosis and hepatic ischemia would produce what level of ALT/
what does AST stand for?
aspartate aminotransferase (found in liver, heart, skeletal muscle, kidney, pancreas and RBC)
what are normal AST values?
how will AST levels change with injury?
elevates at 8hrs
peaks at 24-26 hrs
normal at 3-7 days
what drugs interfere with AST levels?
salicylates, antihypertensive, verapamil, E-mycin, cholinergics, OCP, digoxin, opiates, INH, coumadin
acute renal dz, beriberi, DKA, pregnancy would cause what levels of AST?
liver dz would cause what level of AST/
where is alkaline phosphatase found?
liver, bone, biliary tract
intestine, kidney, placenta, leukocytes
what are normal ALP levels?
what is ALP1 isoenzyme specific for?
what is ALP2 isoenzyme specific for?
hypophosphatemia, malnutrition, milk-alkali syndrome, pernicious anemia and scurvy would cause what level of ALP?
liver dz, normal pregnancy, normal bone growth, bone tumors, fractures, paget dz, and others would cause what levels of ALP?
which drugs interfere with ALP levels?
what is GGT?
where is GGT found?
biliary tract, liver
kidney, spleen, heart, intestine, brain, prostate
what are normal GGT values?
very high in newborns
which is the most sensitive indicator of liver dz?
-indicates heavy and chronic EtOH use
late pregnancy, clofibrate, OCP, will do what to GGT levels?
EtOH, dilantin, liver dz, MI, pancreatic dz and phenobarbital will do what to GGT levels?
what is 5' NT?
where is 5' NT found?
hepatocyte plamsa membrane
what is normal 5'NT value?