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Flashcards in Innate Immunity Deck (39):
1

which areas of the body do not have lymphatic vessels?

CNS
spleen
bone marrow
avascular structures

2

which cells are most abundant in the lymph nodes?

lymphocytes
macrophages

3

what is lymph fluid called?

chyle

4

which two mechanisms facilitate movement of chyle?

contraction of skeletal muscle
respiratory pump

5

what are Hassel's corpuscles/

located in the medulla of the thymus
epithelial cells filled with keratohyaline granules

6

what is the role of nurse cells?

secrete thymic hormones that mature and differentiate T-cells

7

what is located in the outer cortex of lymph nodes?

B cells
macrophages
dendritic cells

8

what is located in the medulla of lymph nodes?

B cells and macrophages

9

what is located in the inner cortex of lymph nodes?

T cells
dendritic cells

10

what CT fibers support lymph nodes?

reticular fiber

11

what is found in the white pulp of the spleen?

B and T cells surrounding branches of the splenic artery
Immune system component

12

what is found in the red pulp of the spleen?

blood-filled venous sinuses
sinusoid capillaries
removes worn out RBC and WBC

13

which chemical on the skin is resistant to bacterial enzymes?

keratin

14

which features do mucosal membranes use to fight bacteria?

acidity
sebum contains chemical toxin
stomach digests proteins
tenacious to trap organisms
cilia to move them out
normal flora

15

which cells produce interferon?

virally-infected lymphocytes and macrophages

16

what does interferon do?

induces synthesis of antiviral proteins

17

which cells produce alpha interferon?

leukocytes

18

which cells produce beta interferon?

fibroblasts

19

which cells produce gamma interferon?

lymphocytes

20

what 3 things does the complement system do?

1. promotes phagocytosis
2. causes inflammation
3. causes cytolysis

21

how does iron binding contribute to innate immunity?

traps iron, which bacteria needs to replicate

22

what do AMP's do?

work in a variety of ways against many organisms

23

which cell has the selectin?

blood vessel endothelial cell

24

which cell has the integrin?

neutrophil

25

what two components does opsonization need?

1. complement (innate)
2. IgG (adaptive)

26

what do defensins do?

pierce a whole in the bacterium cell wall

27

which cells can kill cancer and virally infected cells?

NK cells

28

what important areas contain NK cells?

spleen
bone marrow
lymph nodes

29

how do NK cells know which cells to kill?

contains a stress-induced glycoprotein on cell surface
lacks MHC 1 protein

30

what two proteins do NK cells use to kill cells?

perforins
granzymes

31

what do granzymes do?

penetrate bacterial cells and destroy their insides

32

what are 2 main functions of the inflammatory response?

1. vasodilation
2. increased capillary permeability

33

which 3 things cause pain from injury?

1. edema
2. prostaglandins
3. bradykinin

34

which coagulation factor is responsible for the kinin cascade?

factor 12

35

which prostaglandin is responsible for platelet aggregation?

thrombaxane

36

which prostaglandin is responsible for protecting tissue surrounding the clot?

PGI2

37

what are the 3 results of the complement system?

1. opsonization
2. MAC attack
3. causes inflammation

38

what stimulates zinc and iron binding?

mild-moderate fever

39

what is the role of TLR?

mediate innate immunity when activated

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