Diabetes Pharmacology Flashcards Preview

Medicine > Diabetes Pharmacology > Flashcards

Flashcards in Diabetes Pharmacology Deck (12):
1

when do glucose and insulin levels peak after a meal?

around 60 min

2

which pt has to secrete more insulin in order to maintain stable glucose levels?

obese pts

3

how long do you try a therapy before changing it, typically?

2-3 months

4

what are the primary goals of diabetic therapy?

1. reduce risk of acute and chronic complications
2. foster adherence
3. limit side effects
4. limit cost

5

when using dual or triple therapy, what should you do?

choose two drugs that do different things

6

what is a common first line med for DM?

metformin

7

when does metformin cause lactic acidosis?

drug is excreted in whole by the kidneys and if it hangs around, it will inhibit hepatic metabolism of lactic acid (60% mortality)

8

what is glucagon like peptide?

hormone released by the gut in response to glucose ingestion

9

what does glucagon-like peptide do?

stimulated insulin synthesis and secretion
suppresses glucagon secretion
reduces islet cell apoptosis

10

how is GLP 1 broken down?

DPP-IV

11

how do GLP levels change in type II diabetics?

decreased levels

12

what does DPP-IV do?

inactivates GLP 1

Decks in Medicine Class (146):