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Flashcards in Coagulation Disorders Deck (39):
1

what is the life span of a platelet?

8-10 days

2

how does levonox work?

anti 10a clotting factor medicine

3

what is the most common inherited clotting disorder?

disorder with clotting factor V (factor V leiden)

4

which pathway is tested with the PT study?

extrinsic

5

which pathway is tested with the PTT study?

intrinsic

6

what abnormalities present with problems with clotting cascade?

epistaxis
gum bleeding
hematochexia
melena
petechiae or easy bruising
hemarthrosis**(sometimes the first sign)
menorrhagia
intramuscular hemorrhage

7

what sign points to hemophilia?

spontaneous hemathrosis

8

what is the pneumonic for DDx of bleeding disorders?

CALF DIPS

9

what drug affects the PT time?

coumadin

10

what drug affects the PTT time?

heparin

11

what is the most common inherited disorder of hemostasis?

von willebrand's dz

12

what is the carrier protein for factor VIII?

von willebrand's factor

13

what is the process of primary hemostasis?

platelet plug

14

what is the process of secondary hemostasis?

coagulation cascade

15

how do you use desmopressin in vWD?

give it immediately prior to sx procedure
releases endogenous stored factor VIII from tissues into circulation

16

what is humate used for?

factor VIII replacement that a pt would need post trauma

17

why would you use IVIG in acquired vWD?

may quite down the immune response that is causing the problem with vWD

18

how do vWD factors changed during pregnancy for someone with the dz?

rises in the 2nd and 3rd trimesters and falls quickly postpartum

19

what hemophilia has factor VIII deficiency?

A

20

what hemophilia has factor IX deficiency?

B (christmas dz)

21

what type of genetics is hemophilia?

x-linked

22

when are many hemophilia pts diagnosed?

w/in first 2 years

23

what is a bad complication of hemophilia?

ICH- can cause seizure and long term side effects

24

what joints are most affected in hemophilic joints?

weight bearing joints (hips, knees, ankles)

25

what is common in hemophilia?

massive delayed bleeding and hemorrhage
joint destruction (deposition of iron in joint, pain and decreased ROM)

26

what is considered severe hemophilia dz?

spontaneous bleeding

27

what is considered moderate hemophilia dz?

bleeding with mild injury

28

what is considered mild hemophilia dz?

bleeding with surgery or trauma

29

which type of hemophilia is more common?

hemophilia A

30

what is hemophilia C?

autosomal recessive
factor XI reduced
mild bleeding disorder manifested mostly by post operative bleeding

31

what is FFP?

fresh frozen plasma
what you give to hemophilia C pts b/c recombinant factor XI is not available

32

what is the diagnostic feature of anti-phospholipid antibody syndrome?

abnormal antibodies documented 6 months apart with one pregnancy loss

33

how does a blood clot present?

leg or neck edema
calf or lower leg pain
acute chest pain
SOB
incidental findings

34

what is a VQ scan?

scan that can be used for ppl who can not get a contrast CTA for possible PE

35

what is acute txment of DVT pt?

1. hospitalize and immobilize leg
2. heparin (lovenox)
3. transition to Coumadin a few days later

36

how do you treat elevated homocysteine levels?

B6, B12 and folate

37

how do you calculate risk of DVT?

D D-dimer
A age (>50)
S sex (male)
H hormones (estrogen therapy)

38

what is a normal PT time?

11-16 seconds

39

what is a normal aPTT time?

25-38 seconds

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