Flashcards in Coagulation Disorders Deck (39)
what is the life span of a platelet?
how does levonox work?
anti 10a clotting factor medicine
what is the most common inherited clotting disorder?
disorder with clotting factor V (factor V leiden)
which pathway is tested with the PT study?
which pathway is tested with the PTT study?
what abnormalities present with problems with clotting cascade?
petechiae or easy bruising
hemarthrosis**(sometimes the first sign)
what sign points to hemophilia?
what is the pneumonic for DDx of bleeding disorders?
what drug affects the PT time?
what drug affects the PTT time?
what is the most common inherited disorder of hemostasis?
von willebrand's dz
what is the carrier protein for factor VIII?
von willebrand's factor
what is the process of primary hemostasis?
what is the process of secondary hemostasis?
how do you use desmopressin in vWD?
give it immediately prior to sx procedure
releases endogenous stored factor VIII from tissues into circulation
what is humate used for?
factor VIII replacement that a pt would need post trauma
why would you use IVIG in acquired vWD?
may quite down the immune response that is causing the problem with vWD
how do vWD factors changed during pregnancy for someone with the dz?
rises in the 2nd and 3rd trimesters and falls quickly postpartum
what hemophilia has factor VIII deficiency?
what hemophilia has factor IX deficiency?
B (christmas dz)
what type of genetics is hemophilia?
when are many hemophilia pts diagnosed?
w/in first 2 years
what is a bad complication of hemophilia?
ICH- can cause seizure and long term side effects
what joints are most affected in hemophilic joints?
weight bearing joints (hips, knees, ankles)
what is common in hemophilia?
massive delayed bleeding and hemorrhage
joint destruction (deposition of iron in joint, pain and decreased ROM)
what is considered severe hemophilia dz?
what is considered moderate hemophilia dz?
bleeding with mild injury
what is considered mild hemophilia dz?
bleeding with surgery or trauma
which type of hemophilia is more common?