Renal Day 2 Flashcards Preview

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Flashcards in Renal Day 2 Deck (38):
1

what are macula densa cells?

cells that detect content of tubular fluid to know what to pass through (on distal convoluted tubule that sits next to afferent arteriole)

2

what are mesangial cells?

border glomerulus and function as precapillary sphinters to control pressure through glomerulus

3

what is the tubular pole?

where proxima convoluted tubule emerges off bowman's capusel

4

what are podocytes?

filtration slits that sit outside the fenestrated glomerulus

5

what type of cells makes up the tubules of a nephron?

simple cuboidal with microvilli

6

what type of cells make up the loop of Henle?

simple squamous

7

what is normal plasma osmolarity?

300

8

where does most of reabsorption occur?

proximal convoluted tubule

9

what happens to tubular fluid osmolality as it passes through the loop of Henle?

1. descending osmolality increases
2. ascending osmolality decreases and becomes hypoosmotic
3. collecting duct urine is dilute and has low osmolality

10

what is the normal urine output per day?

1-2L

11

which leg of the loop of Henle is immpermeable to water?

ascending limb

12

which leg of the loop of Henle is not permeable to solutes?

descending loop

13

where are principle cells located?

distal convoluted tubule and collecting duct
-use aldosterone and ADH to reabsorb more water

14

what are intercalated cells?

they control and monitor pH by secretion of hydrogen and potassium into the tubular fluid
located at distal end of DCT

15

where are the two places that contain transitional epithelum?

ureters
bladder

16

what is the triangular area in the bladder?

trigone
ureteral openings and neck of urinary bladder

17

is there a true sphincter in the bladder?

no (contains a physiologic valve)
-ureteral reflux

18

how many layers does the detrusor muscle have?

3 layers of smooth muscle (not skeletal)

19

what is a risk factor for bladder infection?

stasis (urine staying in the bladder)
age causes weakening of muscles

20

what is an intravenous pyelogram?

way to visualize the urinary system

21

what is the rate of secretion?

(glomerular filtration + tubular secretion) - tubular reabsorption

22

how much filtrate is produced each day?

150L f
180L m

23

what is the net filtration pressure at the glomerulus?

10mmHg

24

what is the hydrostatic pressure at the glomerulus?

55mmHg

25

what is the relationship between mesangial cells and filtration rate?

relaxed cell = higher rate
contracted cell = lower rate

26

what is the definition of GFR?

amt of filtrate formed in all the nephrons in both kidneys each minute

27

what happens when GFR is too high?

reabsorbed materials aren't sufficient

28

what happens when GFR is too low?

reabsorbed materials will include some waste

29

when will filtration halt?

when hydrostatic pressure drops below 45mmHg
-when not enough perfusion is coming in

30

what is the lower and upper threshold of MAP at which GFR would change?

80-180mmHg

31

what are the 4 ways in which the kidney autoregulates?

1. myogenic (works w/in seconds)
2. tubuloglomerular feedback
3. neural feedback
4. hormonal feedback

32

if systemic blood pressure is higher, what happens in the kidney?

flow of fluid in the tubular system is faster
macula densa inhibits NO which vasoconstricts afferent arteriole

33

how does sympathetic input impact glomerular?

GFR is decreased b/c afferent constricts more than the efferent
-shunting of blood , shock b/c of hemorrhage, dehydration or stress

34

when does the body make atrial natriuretic peptide?

hypervolemia
-diuresis the body

35

what is paracellular reabsorption?

solutes move across to capillary in between cells

36

what is transcellular reabsorption?

solutes move across to capillary going through the tubular epithelial cells

37

what is a transport maximum?

depends on number of protein transporters and how fast they work
-glucose threshold as example

38

what is a aquaporin 2?

pure water channel (ADH related)

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