Pharmacology Lecture 1 Flashcards
what factors affect Fick’s law of diffusion?
area and thickness of membrane
what is a weak acid drug?
neutral -> protonated + H+
what is a weak base drug?
protonated -> neutral + H+
what form of a weak acid or base is the lipid soluble form?
unprotonated (neutral form)
which form of drug can easily diffuse through the kidney tubule?
lipid soluble (unprotonated)
how would you adjust urine pH to excrete a weak base drug?
make it more acidic (moves drug to the protonated form and can’t pass through tubule)
how would you adjust urine pH to excrete a weak acid drug?
make it more basic (moves drug to the protonated form and can’t pass through tubule)
what is a chemical antagonist?
when one drug binds with another drug in the blood stream thereby prohibiting action of either drug
what is a physiologic antagonist?
when an antagonist acts on a different receptor but opposes another pathway
what are pharmacokinetics?
absorption, distribution, metabolism and excretion of a drug
what the body does to the drug
what are pharmacodynamics?
non-receptor or receptor mechanisms
what the drug does to the body
what is an additive affect?
when two drugs have to work together to make an effect?
2+2 = 4
what is synergistic?
when two drugs working together make a better effect
2 + 2 = 4 + 4
what is potentiation?
when one drug improves the performance of another drug
2+ 2 = 4 + 2
in the case of a contraindication you would…
never ever ever give the drug