Hematology and Anemias Flashcards Preview

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Flashcards in Hematology and Anemias Deck (65):
1

hypoproliferation

decreased production of RBC
OR produced defective RBC

2

hemolysis

increased destruction of RBC

3

hemorrhage

blood loss produces anemia

4

erythropoeitin (Epo)

produced in the kidney which senses hypoxia

5

common symptoms of anemia are

weakness and fatigue

6

anemia due to decreased O2 transport presents with

fatigue
dsypnea
angina

7

anemia due to decreased blood volume presents with

pallor
postural hypotension
syncope
headache
tinnitus (ringing in the ears)

8

anemia due to decreased cardiac output presents with

tachycardia
systolic ejection (heart murmur)
lightheaded

9

anemia due to hemolysis of RBC presents with

jaundice
splenomegaly

10

3 tests that indicate iron deficiency anemia

1. serum iron
2. total binding iron capacity (TIBC)
3. ferritin

11

serum iron normal value

60-170 mcg/dcl

12

TIBC normal value

measurement of transferrin
240-450 mcg/dcl

13

ferritin normal value

measurement of amount of ferritin in blood
male 12-300 ng/ml
female 12-150 ng/ml

14

site of absorption of iron

duodenum and upper jejunum

15

site of absorption of B12

terminal ileum and stored in liver

16

pernicious anemia

lack of intrinsic factor of autoimmune destruction of parietal cells

17

2 tests to indicate B12 anemia

1. CBC
2. serum B12

18

normal serum B12 reading

160-950 pg/dl

19

site of absorption of folate/folic acid

proximal jejunum

20

normal range of folate

2.7-17.0 ng/ml

21

test to indicate folate anemia

CBC (macrocytic anemia)

22

chronic GI bleed would have

decreased serum iron
decreased ferritin

23

Heavy menstrual bleeding would have

decreased serum iron
decreased ferritin

24

malabsorption of iron would have

decreased serum iron

25

insufficient dietary iron would have

low serum iron

26

pregnancy would have

low serum iron
high TIBC

27

anemia of chronic disease would have

low serum iron
low TIBC
high ferritin

28

iron deficiency anemia would have

decreased serum iron
increased TIBC
decreased ferritin

28

hemolytic anemias would have

high serum iron
low TIBC (free iron is binding to transferrin)
high ferritin

29

hemosiderosis/hemochromatosis would have

high serum iron
high TIBC
high ferritin

30

hepatic necrosis would have

high serum iron

31

hepatitis and cirrhosis would have

high serum iron
low TIBC
high ferritin

32

vitamin B deficiency would have

high serum iron
low TIBC

33

iron poisoning would have

high serum iron

34

multiple blood transfusions would have

high serum iron

35

sickle cell anemia would have

high serum iron
low TIBC

36

hypoproteinemia would have

low TIBC

37

Polycythemia vera would have

high TIBC

38

Contraceptives (OCPs) could cause

high TIBC
low serum B12
low serum folate

39

Hodgkins lymphoma would have

high ferritin

40

megaloblastic (macrocytic) anemia would have

high ferritin

41

any inflammatory disorder would have

high ferritin

42

sideroblastic anemai would have

body produces ringed sideroblasts, instead of healthy RBC
high serum iron
normal TIBC
high ferritin

43

vitamin B12 is obtained by the body through

dietary sources (meats, cheese, milk and eggs)

44

folate is obtained by the body through

dietary sources (leafy greens, liver and eggs)

45

iron deficiency anemia is a

microcytic anemia

46

anemia of chronic disease can be

microcytic or normoocytic

47

thalassemia is a

microcytic anemia

48

sideroblastic anemia is a

microcytic anemia

49

lead poisoning is a

microcytic anemia

50

renal failure causes

normocytic anemia

51

myelodysplastic syndrome causes

normocytic and macrocytic anemia

52

endocrinopathy causes

normocytic anemia

53

aplastic anemia is a

normocytic anemia

54

RBC aplasia is a

normocytic anemia

55

myelofibrosis causes

normocytic anemia

56

myelophthisis causes

normocytic anemia

57

hemolytic anemia with low retic count can be

normocytic or macrocytic anemia

58

mixed micro and macrocytic anemia can present as

normocytic anemia

59

multiple myeloma causes

normocytic anemia

60

pernicious anemia is a

macrocytic anemia
specific type of vitamin B deficiency where by parietal cells of the stomach are killed and no longer secrete instrinsic factor which is needed by the ileum to absorb vitamin B

61

folate deficiency is a

macrocytic anemia

62

alcohol and drugs causes

macrocytic anemia

63

hypothyroidism causes

macrocytic anemia

64

liver disease causes

macrocytic anemia

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