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Flashcards in cardiac meds Deck (24):
1

4 major athero targets for drugs

1. large lipid core
- lower chol.
- reduce inflammation
2. thin fibrous cap
- stabilize
3. endothelium
- inprove function
4. thrombus
- anti-platelet
- anti-coag.

2

target of a statin

inhibit acteyl CoA, so can't synthesize chol.

3

effects of statins on LDL

atorvastatin - 40-50%
rosuvastatin - 50-60%

4

4 other chol. drugs and their effects

1. Cholestramine - resin - 20-30
2. ezetimibe - block GI absorb - 20
3. ibrates - 20
4. niacin - 30, also raises HDL

5

what is new lipid drug

PCSK9 inhibitor
- don't break down LDL-r, so pull in more to the liver
- another 50% reduciton

6

3 main targets to stop platelet activation

1. ADP
2. COX
3. fibrinogen

7

main COX blocker for the heart

ASA

8

ASA effects

less strokes and coronary events

9

what are ADP blockers (4)

1 .clopidigrel
2. ticlopidine
3. ticagrelor
4. prasugrel

10

what is effect of ADP blockers

more effective than ASA, but more expensive too

11

what are GP2b/3a inhibs

abciximab to stop final step of platelet aggregation

12

what are 2 old anti-coags and what did they do

1. warfarin - blocks 10a
2. heparin - blocks thrombin

13

issues with old ones

- hard to dose
- need monitoring

14

new option to heparin

LMWH - fractionated
- dose is clear

15

what are new oral anti-coags

1. apixaban and rivaroxiban
- both with in 10a
2. dabigatran
- works on thrombin

16

adv. of new ones

stable dosing
- no need to monitor
- not as easy to reverse though

17

what are clot busters

streptokinase (tPa)
- help form plasmin faster, which breaks down fibrin

18

2 main classes to improve endothelial function

ACEis
ARBs

19

4 main effects of ACE and ARB

1. vasodilation
2. renal preservation
3. endothelial stabilization
4. cardiac protection

20

use for nitrates

helps supply of blood

21

4 ways to give nitrates

1. SL - rapid onset, short duration
2. oral - tachyphylaxis
3. topical
4. IV

22

2 main actions of Bblockers

1. reduce HR
2. reduce contracttility

23

**2 main types of BB

1. non-selective B1 and B2
- propranalol
2. selective for B1
- atenalol
- metopralol

24

3 main actions of CCBs

1. smooth muscle relax on vessel walls
2. SA and AV node slowing
3. slow contraction in myocardium

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