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Flashcards in Reproductive dev Deck (50):
1

Def. of genetic sex

based on the XY chromos

2

Aspects of phenotypic sex (3)

1. gonads
2. accessory glands
3. genitals

3

Path of normal dev.

genotype>gonads>hormones>glands and genitals

4

Age at which anatomical diffs become apparent

7 weeks

5

location of gonads at first appearance

post abdo wall medial to mesonephros

6

2 tissues making up gonads

1. core of mesoderm
2. epithelium covering

7

what stimulates further dev of gonads?

primordial germ cells at the genital ridge

8

Path of ovary dev (3 steps)

1. No Y > sex cord fragments
2. Germ cells become oogonia
3. Sex cord cells become follicular cells

9

What becomes of sex cords in male and female

1. Male - seminiferous tubes
2. Female - Follicular cells

10

Steps of test dev.

1. Y present > sex cords become seminiferous tubes
2. Sex cords for sertoli cells> antimuellerian factor
3. Mesoderm cells become leydig cells > testosterone
4. primordial germ cells become spermatogonia

11

Importance of SRY

Actual part of Y that defines dev.

12

2 phases of test. descent

1. trans-abdo phase - passive - gubernaculum stays while rest grows
2. Trans-inguinal - active, but not known how

13

peritoneum that pulls down with testies

processus vaginalis

14

2 abnormalities of test descent

1. cryptocord testis - not fully into scrotum
2. ectopic testis - through ring, but not in scrotum

15

Abnormality of processus vag.

hydrocele

16

other names of paramesonepthric ducts and mesonephric ducts

para - mullerian
meso - wolfian

17

what mullerian ducts fuse to form

uterovaginal primordium

18

what contact between uterovaginal primordium and urogential sinus create

vaginal plate

19

function of anti-mullerian hormone in male

degenerates uretrovaginal promordium (become utricle and appendix of testes)

20

What androgens induce (3)

1. mesoneprhic excretory tubes become efferent ductules
2. mesonephric duct becomes epidyd, vas def, ejaculatory duct
3. seminal vesicles dev out of mesonephric ducts

21

what happens if no Y (3)

1. parameso nephric duct - uterine tubes
2. uterovag primordium - uterus
3. mesonephric ducts degenerate

22

what tissues form vagina

1. uterovaginal primordium
2. endoderm from urogenital sinus

23

Age until which genitals can't be distiguished

week 9

24

3 indifferent genital swellings

1. genital tubercle
2. urogenital fold
3. labioscrotal fold

25

What becomes of genital swellings in females

1. genital tubercle - clit
2. urogenital fold - labia min
3. labioscrotal fold - labia maj

26

What becomes of genital swellings in males

1. genital tubercle - glans penis
2. urogenital fold - folds to urethra
3. labioscrotal fold - scrotum

27

problems with urogential folding

hypospadias

28

path of test.

test>5 alpha reductase>DHT

29

source of gonadal tissue (3)

1. mesothelium
2. mesenchyme
3. primordial germ cells

30

source of primordial germ cells

endodermal cells in yolk sac

31

source of semniferous cords

gonadal cords

32

cells that separate seminiferous cords

leydig cells

33

producer of anti-mullerian

sertoli cells

34

fate of the mesonephric duct in males

duct of epidydimis

35

proper names of mullerian and wolfian ducts

mullerian: paramesonephric
wolfian: mesonephric ducts

36

fate of mesonephric duct on males and females

males: epidyd and vas
females: disappears

37

fate of parameso ducts

male: disappear
female: uretovaginal primordium

38

tissue source of seminal gland

mesonephro duct

39

tissue source of epoopheron

mesonephric

40

tissue source of gubernaculum

mesonephros

41

time of testes descent

28th week

42

location of test. descent relative to processus

posterior

43

location of DAX-1

X chromosome

44

point where T is converted to DHT

urogenital sinus

45

Karyotype, gonads, male and female ducts, genitals of 5 alpha reductase deficiency

Karyotype - XY
Gonads - male
Male ducts - present
Female ducts - absent
Genitals - feminized

46

Karyotype, gonads, male and female ducts, genitals of virilizing hyperplasia

Karyotype - XX
Gonads - female
Male ducts - no, missed sensitive period
Female ducts - present
Genitals - masc.

47

Karyotype, gonads, male and female ducts, genitals of congenital dysgenisis

Karyotype - XY
Gonads - none
Male ducts - absent
Female ducts - present
Genitals - immature female

48

Karyotype, gonads, male and female ducts, genitals of androgen resistance

Karyotype - XY
Gonads - male
Male ducts - no
Female ducts - no
Genitals - feminized

49

path in congenital hyperplasia

hypothalmus>cortisol reducing factor>pit>ACTH>adrenal>cortisol and biproduct of androgens

50

result of leftover mesonephric duct in women

ovary- epoopharon
urterus - gartner's cyst

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