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Flashcards in Lab tests Deck (23):
1

def. bayes theorem

clinical utility of a test is best when pre-test prob is intermediate

2

5 tests for SLE

1. ANA
2. anti dsDNA
3. ENA
4. serum complements
5. antiphospholipid AB

3

def. ANA

ABs that react with nuclear antigens

4

sens and spec of ANA for SLE

sens - 95-100
spec - not very

5

implications of this

if have no ANA - not SLE
but if have, it can be something else

6

implications of staining patterns

not very helpful

7

what can be helpful with ANA

very high concentrations can be correlated

8

Sens and spec of dsDNA

sens - medium for SLE
spec - very high

9

what else if dsDNA good for

can be good for following disease if they are concordant

10

what is tested for in complement

tends to be used up and go down in SLE

11

what is RF

AB that binds to Fc of other ABs

12

sens and spec of RF

sens - medium
spec - poor
- not a great test

13

when is testing for RF most useful

when already have moderate probability based of hist

14

what is anti CCP

AB against AA formed from arginine
- useful in RA

15

sens and spec of antiCCP

sens - medium
spec - good

16

what is anti CCP takehome

- detectable in early disease
- more spec. than RF
- not useful in measuring other disease

17

what is acute phase response

- within hours of inflamm
- early def. mech
- major inducers IL1,6, TNF

18

when is acute phase response

- infection
- inflammation
- neoplastic
- trauma

19

2 acute phase reactant tests

1. ESR
2. CRP

20

disadv. of ESR

- affected by age and gender
- affected by RBC morpp
- many plasma proteins
- requires fresh sample

21

disadv. of CRP

$$

22

take home for acute phase reactants

- little diagnositc value
- too sens
- not specific
- may be useful for following disease

23

what is use of creat. and urinanalysis

physical exam of the kidney

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