Immunosuppresive drugs Flashcards Preview

Undeleted > Immunosuppresive drugs > Flashcards

Flashcards in Immunosuppresive drugs Deck (28):
1

6 general classes

1. corticosteroids
2. antiproliferative agents
3. agents that block T-cell activation
4. antibodies
5. fusion proteins
6. other

2

2 uses for IS drugs

self - autoimmune
non-self - transplant

3

4 ways to classify IS

1. action on one or multiple systems?
2. target in or outside of cell
3. action inside or outside of cell
4. large protein or small molecule

4

what is effect of IS on cancer

some meds for cancer (hematologic) can be IS, but in other cases IS can cause malignancies

5

2 risks with IS

1. infection - varies based on degree, type of infeciton
2. malignancy

6

mech of action of glucocorticoids

bind to gluco-R and unreg or downreg gene transcription

7

most common glucocort

PO - prednisone, many other routes of administration

8

possible cort. dosing

1. pulse
2. high dose and taper
3. short course
4. chronic low dose
5. topical

9

SE of corts.

HT, infection, hyperlipidemia, weight gain, skin chnages, osteopenia/porosis, muscle atrphy ........

10

what are antiproliferative agents

1. prevent proliferation of lymphocytes causing attack or rejection
2. bone marrow supression

11

what is cyclophosphamide

alkylating agent used in oncology
- crosslinks with DNA - cell death
-SE = hematuria, neutropenia, ovarian failure

12

main MOA in antiproliferatives

prevent DNA synthesis - cell can't reporduce

13

what is sirolimus

block mTOR - cell can;t progress from G1- s phase of mitosis

14

what are calcineurin inhibitors

block T cell response by not allowing transcription of IL-2, so don't get Tcell activaiton

15

indications for calcineurin inhib.

1. transplant
2. glomerulonephritis
3. psoriasis
4. RA
5. opthalmic disease

16

what is rationale behind AB use

find specific target to block in given disease (cell surface recptors, serum molecules)

17

what are most antibody types in use

monoclonal - to specific antigen

18

probs. with monocloncal antibodies (2)

1. anti AB AB can dev.
2. increases risk of infection and malignanacy

19

what is a chimeric AB

part human and part mouse or other animal

20

2 examples of mABs

Basiliximab - binds to IL-2 receptor on T-cell
Infliximab - and TNF AB, also leads to apop of TNF producing cells

21

what is thymoglobin

- polyclonal AB
- against 40+ antigens
- mainly active against T-cell - prevent avtivation and binds and clears from that system
SE = prolonged and profound lymphopenia

22

what is IVIg

pooled immunoglobin from many donors
- multiple mech of action

23

IVIg mechs

1. inhib ABs
2. inhibs complement
3. inhibs B-cells
4. inhibs adehesion molecules

24

adv and dis of IVIg

well tolerated
- lo risk of infection or malig
- limited supply
- expensive

25

what is fusion protien

join together - receptor to target antigen with Fc of an antibody

- cept

26

MOA of fusion protein

prevents molecule from binding and activation

27

what is etanercept

TNF blocker
- fusion of TNF -R and Fc IgG

28

2 other types. of IS drugs

1. sulfa drugs - MOA unknown
2. hydrochloroquinine - for malaria

Decks in Undeleted Class (589):