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Flashcards in pharma of adrenal corticosteroids Deck (19):
1

function of mineralcorticoids (3)

1. conserve Na and H2O
2. ionic balance
3. blood volume and pressure

2

fucntions of glucocorticoids (4)

1. metabolic effects
2. brain and behaviour
3. endocrine systems
4. immune system

3

how does cortisol work

1. bound to CBG
2. passes membrane to bind receptor
3. binds to DNA and changes transcription
4. altered cells function follows

4

what are 3 mechanisms of cortisol

1. release of protein kinase from cytosolic receptor
2. membrane effects
3. receptor mediated membrane effects

5

what does HSD2 do?

dehydoxylates cortisol to make cortisone

6

what are spironolactone and eplerenone

MC antagonsits

7

what do they treat

primary and secondary hyperaldosteronism - edem a and hypertension

8

what are advantages of aldosterone and cortisol analogs

1. longer acting and more potent
2. separate CG and MC componentns

9

what is GC:MC ratio of prenisolone compared to cortisol

4:0.3

10

what is GC:MC ratio of fludrocortisone compared to cortisol

10:250

11

what is GC:MC ratio of dexamethosone compared to cortisol

25:0

12

what is specific about cortisone and prednisone

both need to be converted in body

13

what is adv of cortisone and prednisone

can be given orally

14

what are clinical uses of adrenal homones

1. replacement therapy (adrenal insuff., CAH)
2. antiinflammatory - antiallergy
3. Cancer treatement

15

what are drugs used in replacement treatment

1. hydrocortisone 15-20 mg/day
2. fludrocortisone 3-4mg/day

16

how does anti-inflammatory treatment work?

1. inhibs WBCs
2. inhibs proteolytic enzymes
3. inhibs walling off and scar formation

17

what is needed to be careful of in therapy

1. okay in acute doses
2. chronic doses should be kept small

18

what are 3 cancers they are used for?

1. lymphomas and leukemias
2. androgen dependent tumors
3. hypercalcemia in bone mets

19

2 side effects

1. MC activity - hypertension
2. ACTH supression - cushing's like

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