Peptic ulcer disease Flashcards Preview

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Flashcards in Peptic ulcer disease Deck (16):
1

6 main causes of upper GI bleed

1. peptic ulcer
2. esophagitis
3. gastritis
4. mallory weiss
5. varices
6. malignancy

2

causes of peptic ulcer (3)

1. idiopathic
2. primary - h.pylori
3. secondary

3

secondary causes of ulcer (4)

1. drug toxins (NSAIDs, crack)
2. excess acid
3. stress
4. ischemic/inflammatory

4

where are NSAIDs more likely to effect

stomach

5

2 key mechanisms that NSAID work by

1. direct effect on epithelial lining
2. COX-1 inhibition leads to poor clotting

6

mech of h pylori

1. burrows in stomach
2. produces urease
3. catalyzes urea to bicarb to protect self
4. allows attachement to epi.

7

3 demo graphics of h.pylori

1. community clusters
2. inverse proportion to socioecon status
3. prev increase with age

8

**what is prob with serology test for h pylori

once you have it will always test pos. even when it is eradicated - can't use for treatment follow-up

9

3 h.pylori phenotypes

1. duodenal ulcer - in antrum
2. simple gastritis - mild througout
3. gastric cancer - fundus and body

10

feat. of duodenal ulcer

high gastrin and acid secretion - acid goes into duod

11

feat of simple gastririts

high gastrin, but normal acid - no sig. clinical outcome

12

feat of gastric cancer type

high gastrin, but low acid - risk of cancer

13

3 gen. factors that influence severity of infection

1. host genes
2. bacterial virulence
3. env. factors

14

4 steps of treatment

1. ABCs - close monitoring
2. stop offending agents
3. endoscopic
4. medical

15

2 principle of med mgmt

1. increase pH - proton pump inhib
2. cytoprotection

16

outcomes if eradicate hpylori

1. GU 97%
22 DU 98%

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