Gastric CA Flashcards Preview

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Flashcards in Gastric CA Deck (19):
1

main type of gastric CA

adenocarcinoma
- but also lymphoma, carcinoid

2

2 main types

1. intestinal types
2. diffuse type

3

epi

2nd leading cause of CA death worldwide
- men>women'
- regional variation

4

main intestinal type risk factor

h. pylori - via chronic inflammation

5

other intestinal risk factors

- diet (salt, nitrites)
- obese
- smoking
- prior surg

6

risk for diffuse type

- younger
- hereditary in some
- mutation in e-cadherin

7

2 classification systems

lauern (diffuse vs. intestinal)
WHO - not used

8

what is seen in intestinal type

central ulcer in folds

9

what is seen in diffuse type

signet rings
- mucin vacuoles

10

what does grading tell us

how fast - degree of differentiation

11

what is grading scheme

G1-G4 - with 4 being least diff.
- diffuse type is automatically G3

12

what is stage based on (3)

TNM

13

what are 3 margins

1. proximal margin - eso
2. distal - duodenum
3. omental (radial) margin

14

3 additional parameters

1. lymphatic invasion (small vessel)
2. venous
3. perineural

15

clinical features

if early - asymtomatic
- weight loss
- Fe def.
- obtruction

16

what is used for diagnosis

endo - tissue
- look at ulcer

17

how to stage

early - Endo US
CT

18

treatment for diff. severities

mucosal - endo removal
submucosal - total or oartial gastrectomy - adj. chemo
advanced - chemo/rad

19

overall pronosis

poor

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