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Flashcards in Gastric function Deck (24):
1

5 gastric functions

1. reservoir
2. begins digestion (breaks food into small 2mm)
3. delivers food to duodenum
4. produces gastric juice
5. protects against micro-organisms

2

3 muscle functions of stomach

1. receptive relaxation
2. trituration - making chyme
3. emptying

3

where is cutoff to 2 different glandular mucosa of stomach

between body and antrum

4

2 main types of stomach glands

1. oxyntic - body and fundus
2. plyoric

5

6 cell types of oxyntic glands - and secretions

1. surface cells
2. mucous neck cells
3. enterochromaffin cells - histamine
4. D cells - somatostatin
5. parietal cells - acid
6. chief cells - pepsinogin

6

what is a paracrine cell

cell that affects the actions of the cell next to it

7

special cell of pyloric gland

G cell - gastrin

8

how does parietal cell work

CO2 + H2O become H2CO3 > H + HCO3-
H is secreted into stomach by K/H ATPase and HCO3 into blood

9

3 main signals of gastric acid production

1. gastrin
2. histamine
3. acth

10

function of histamine

produced by ECL cell to tell parietal cell to secrete acid

11

function of gastrin (2)

1. directly tell parietal cell to secrete acid
2. tells ECL to secret histamine

12

function of ACTH (3)

1. tells parietal cell to secrete acid directly
2. stims G cells
3. stims ECL cells

13

what stims gastrin production (4)

1. antral ditension (full)
2. AAs
3. vagal stim - see food
4. rising pH

14

what stims histamine release (2)

1. gastrin
2. vagal nerve

15

how is acid secretion inhibited in stomach?

1. low pH
2. stims D cell to release somatostatin
3. somatostatin is inhib to G cells
4. gastrin lowered

16

how is acid secretion inhibited by duodenum?

enterogastric reflex
1. food in duodenum
2. secretin and CCK released from duod.
3. CCK stims somatostain and inhib gastrin
4. secretin inhibs gastrin and parietal cells directly

17

3 places gastric acid signalling comes from

1. cephalic (20%
2. gastric 70%
3. duodenum 10%

18

what is mucosal barrier

1. mucus by mucous cels stimulated by food contents
2. epithelium secretes alkaline fluid in and stuck inmucous to protect stomach lining

19

function of gastric pepsin

primary protease

20

what stims gastric pepsin

ACH along with acid

21

what does chief cell secrete

pepsinogen - cleaved to pepsin by acid

22

function of intrinsic factor

binding of B12 for absorbtion

23

function of gastric lipase

hydrolysis of triglycerides

24

what is absorbed in stomach

very little - alcohol and ASA

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