atherosclerotic disease Flashcards Preview

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Flashcards in atherosclerotic disease Deck (17):
1

what is atherosclerosis

patho process of forming atheroma

2

major risk factor

age - espeially after 40

3

what layer of the vessel is affected

intima, and as gets worse, media

4

3 major areas most likely to be affected

1. branch points
2. curvatures
3. regions of complex blood flow

5

6 systems affected by athero

1. CAD
2. AAA
3. CV disease
4. PVD
5. mesenteric
6. renovascular

6

what part of vessel is major regulator of activity

enodthelium

7

6 features of the endo thelium

1. anti-inflamm
2. atni -thrombotic
3 anti- proliferative
4. anti-oxiadative
5. vasodilatory
6. selectively permeable

8

what happens in athero

1. shear stress
2. LDL in
3. macros eat them
4. foam cells
5. smooth msucle enters

9

3 types of athero

stable atheroma with:
1. thin fibrous cap over a necrotic core
2. stable fibromuscular cap
3. stable fibro calcific cap

10

2 things that can happen when cap breaks

1. non-occlusive thrombus
2. occlusive thrombus forms

11

what are 4 features of MI

1. acute coag. necrosis
2. usually in area supplied by occluded art
3. LV most common
4. starts in sub endocardial zone and may become mural

12

3 stages of MI and what is seen

1. early - contraction bands
2. 16-24 hours - acute inflammation
3. days - early healing and macrophages with loss of myocytes

13

6 possible compliations of MI

1. arrhymia
2. free wall/septal rupture
3. mittral insuff.
4. papillary muscle rupture
5. aneurysm
6. CHF

14

what is sudden death in athero

most sudden death not due to athero (unless severe) but likely an arrythmia triggered by the infarct
- usually die at home, not hospital

15

what amount of steonis is likely to leasd to death

70-75-%

16

2 possible interventions

1. stents
2. bypass graft - art or vein used
- art. is better

17

what happens to the kidney

chronic reno-vascual hypertension
- low flow to kidney
RAS activation

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