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Flashcards in Depression Deck (14):
1

#1 cause of disability in CAn

depression

2

DSM crit of depression

5 of:
1. depressed mood
2. loss of interest
3. weight loss or gain
4. insomnia or hypoersomnia
5. psychomotor agitation or retardation
6. fatigue
7. worthlessness or guilt
8. concentrations
9. thoughts of death/suicide

3

4 DSM caveats

1. not mixed disorder
2. cause distress
3. not due to substance
4. not due to bereavment over 2 months

4

2 most heritable disorders and 1 least

2 most - ASD and SCHZ
1 least - depress

5

what is HPA and depression regulation

poor cortisol supression in people with depressiokns

6

what is gene environment interaction in depression

certain genes mix with stressful life events to cause depression

7

what is "S" allele

short allele causing less 5HT transcription and related to more depression with stressors

8

what is brain effect of chronic social defeat

downregulation of BDNF through DNA methylation

9

what happens when give antidpressants

reverses effects of DNA methylation through histone acetylation

10

what is overall effect of social isolation

leave a lasting molecular scar that can be circumvented but not directly reversed by antidepressent meds

11

3 ways depression and BDNF are related

1. severe stress reduces hippocampal BDNF
2. excessive cortisol could affect BDNF transcription
3. antidepressants increase BDNF expression and dendrites

12

what is effect of excercise

increase in # of neurons in hippocampus

13

what is ECT effect

almost double effect of antidepressants and antihypertnesives

14

3 ways hippocampus is important in reg. of mood

1. deficiencies in hippo impair ability to make positive new contexts
2. reductions in hippo leave fear feelings context free
3. restoring hippocamp can help restore and recontextulaize the fear memories

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