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Flashcards in Calculating drug doses Deck (32):
1

what is is dose

amount of drug to be given

2

what is doage

amount of drug to be given per time

3

2 ways to determine dose

1. follow guidelines taking PT into account
2. look up drug properties and then use formulas

4

how to deterimine the target [C] (2)

1. look up in monograph
2. use Sx as surrogate

5

what is caveat to [c] rules

the [c] does not always correspond to the effect - eg THC

6

2 issues in calcualting dose

1. form/route
2. speed of delivery (need loading dose?)

7

dose formula

dose = (target [c])xVd

8

what is dose formula is not paraenteral

dose = (CxVd)/(bioavailability (F))

9

what is bioequivalence

comparapable plasma [c]

10

what is therapeutic equivalence

comparable clinical effectiveness

11

what are 2 assumptions for single dose

1. all dose distributed into this volume quickly
2. use calculation of initial [c]

12

how long until reach steady state

4-5 half lives

13

how to get to steady state faster

loading dose

14

what is clearance rate

rate of elim./plasma drug [c]

15

what is differential [c] formula

C=C0e -kt

16

what is t.5 forlmula

ln2/ke

17

what is formula for ke from log graph

(2.303)(-slope)

18

what is clearance rate formula

Cl = Ke x Vd

19

what is Ke

constant for rate of elimination

20

what is steady state formula

rate of infusion/rate of elimination

21

what is formula for using a loading dose to get to steady state [c]

dose = Css * Vd

22

if giving repeated dosing, where should doses be kept

between [C]toxic and [c]therapeutic

23

what is loading dose formula for oral drugs

(Ctarget * Vd)/F

24

what does % mean

1g/100ml

25

what is the drip rate

number of drops per minute

26

what is the drop factor

number of drops in 1 ml

27

what are 2 general types of drip tubing

microdrip and macrodrip

28

what is IV flow rate calculation

(volume ordered*drop factor)/time to infuse

29

what is time remaining formula

current vol/pump setting(ml/h)

30

4 components to a prescription

1. superscription (patient and presciber info)
2. inscription (drug, amount, strength)
3. subscription (directions to pharmacist regarding number and form)
4. signatura (directions to the PT)

31

what is adherance

actually taking the drug

32

what contrubutes to non-compliance (6)

1. complexity of taking
2. convenience
3. adverse effects
4. understanding disease state
5. belief in treatment
6. cost

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