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Flashcards in Myloid cells Deck (29):
1

sims and diffs. in adults vs. children marrrow

same amount, but only axial bones in adults

2

2 diff. marrow tests

1. aspirate - liquid marrow - know cell types
2. biopsy - plug - can see neighborhoods

3

def. of myloid cell

any cell that isn't a myphocyte

4

2 important features of stem cells

1. pluripotent
2. self-renewal

5

3 feats. of progentior cell

1. commited
2. rapid prolif.
3. limited self-renewal

6

path of cell production

stem cell>progenitor>precursor>end cell

7

feats. of mature blood cell

1. one lineage
2. no proliferation
3. terminal

8

3 steps of cell formation

1. hematopoetic cells interact with marrow env.
2. hemat. cells home to bone marrow
3. mature cells leave via sinusoids

9

def. of transcription factor

gene/protein which can influence multiple other genes

10

what stimulates blood cell production

cytokines

11

cytokine for neutrophil dev.

G-CSF

12

where do most neutrophils hang out

in marrow and margin around the vessel

13

life smap and feat. or neutrophil

half-life of 6 hours
mostly in marrow
no cell division

14

4 types of WBCs and what they do

1. neutrophil - move in to destroy and clear
2. eosonphil - defense against helminths, parasites, hypersensitivty reactions
3. basophils - effector in hypersensitivity
4. monocytes/macrophages - phagocytos, antigen presenters

15

****6 steps of neutrophil response

1. rolling
2. adhesion
3. dispedsis/transmigration
4. chemotaxis
5. phagocytosis
6. microbicidal activity

16

what happens if neutropenia

- too few neutrophils - infections!

17

treatment for congenital neutropenia

give G-CSF

18

problems with neutrophil function (2)

1. insufficiant adhesion - don't attache to wall
2. insufficiant oxidative cap. - don't break stuff down

19

how neutrophil knows to roll

selectins on vessel wall

20

how neutrophil know to adhesion

integrins on neutrophil membrane

21

conseq. of adhesion probs.

high neutophil count, but no pus
- lots of infection and death before 2

22

conseq. of oxidation probs.

creates masses

23

define leukemia

accumulation of immature blast cells

24

define acute myeloid leukemia

blast express one of several myeloid phenotypes

25

2 different classes of myloid mutations

1. proliferation and survival
2. impaired differentiation

26

mechanism of leukemia mutations

- translocation convert transcription factor from activator to repressor
- then doesn't differentiate cells to end cells

27

what do chemo drugs do?

kill dividing cells

28

what determines duration between courses in chemo?

neutrophil recovery time

29

3 things neutrophils use to accomplish their tasks

1. granule contents
2. surface receptors
3. enzyme activity

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