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Flashcards in Geri pharma Deck (22):
1

def. adverse drug event

an injury resulting from admin of a drug

2

3 pharma factors influenced by ageing

1. pharmcokinteitc - how body handles drugs
2. pharmacodynamics - how drug affects body
3. drug-drug interactions

3

4 parts of pharmacokinetics

1. absorbtion
2. dist.
3. meatbolism
4. elim

4

what influences a drug's bioavailality

- drug liberation
- gastic motlity
- drug properties
- drug transporters
- drug metabolsim

5

2 gastic issues with age

1. higher gastic pH
2. less motility - slower to act

6

how to change oral dosing with age

- no sig. need to change practices

7

what are 3 effects of aging skine

- sun exposure
- less blood supply
- less water contenet

8

3 ways vol. of dist changes with age and how it affects

1. more fat
- longer half life of lipoohillic drugs - benzos
2. less water
- larger conc. of lipo phillic drugs - digoxins
3. less protein binding cap

9

2 phases of metabolism and how they change with age

1. - CYPs
- decreases by 30%
2. conjugation
- no chnage
overall need to give a lower loading dose

10

2 general ways drugs are removed

1. passive - renal
2. active - drug transporters

11

how does renal function change

- less nephrons
- less blood flow
- less GFR
- need to be cautious about renal drugs

12

3 renal drugs to be extra careful with

1. lithium
2. digoxin
3. sulfonourea

13

ADME summary

A - less acid in stomach
D - langer half life and altered C
M - less liver metabolism
E - less kidney function

14

2 main dynamic changes with age

1. drug-drug interaction
2. increased sens. to cog effects

15

3 more sens to and 2 less sens. to

more
- sedatives
- opiods
- antichol
less
- BB
- A stims

16

what is prob with benzos

CNS depression
- falls
- delirium
- less cog

17

use zoplicone

- no, just as bad - no safe sleeping pill

18

what is prescription cascade

giving drugs to Tx SE of previous drugs

19

4 methods to help prevent ADE

1. computerized physician ordering
2. multidisc. support
3. patient educaiton
4. assessment of meds apporpriatness

20

2 ways to assess appropriateness

1. beers criteria
2. med appropriatness index

21

ris factors for not adhering

- polypharma
- cog issues
- funct. issues
- poor contact
- poor social supprt
- no assisstance with med. admin

22

3 ways to improve adherence

1. med. dispensing aids
2. meds review
3. patient ed

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