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Flashcards in Depression Deck (26):
1

**what causes the largerst global burden of disease

depression

2

**features of depression episode

M - mood
S - sleep
I - interest
G - guilt
E - energy
C - concentration
A - appetitie/weight
P - psychomotor retarded
S - suicidal

3

what is episode vs. disorder

- episode is deiscrete period
- MDE can be part of another disorder
- MDD requires it not being better explianed by another disorder

4

DDx for depression

1. bipolar
2. persistent depressive dis
3. premenstrual DD
4. substance induced DD
5. DD due to GMC
6. adjustment with depressed mood
7. bereavement

5

def. bipolar

type 1 - manic episode
type 2 - hypomania and MDE required - no mania allowed

6

def. persistent DD

depression for most of the day, for more days than not for 2 years

7

def. PMDD

mood in week before period and then goes away
- impariment

8

3 keys to substance induced MD

- occurs after substance
- persists after substance stopped
- can be meds

9

what is adjustment disorder with depressed mood

Sx that come within 3 months of a stressor and go away within 6 months
- don't meet MDE requirements

10

lifetime prev of depression

10-20%

11

what is trigger for first and subsequent depression

1st - multiple stressors
after - don't always seem to have stressors - at risk

12

what are 3 major monaamines of depression

- 5HT
- NE
- DA

13

what are treatments for types of depresison

mild/mod - CBT and IPT
severe - drugs +/- therapy
best with both

14

6 main classes of anti-dep

SSRI
SNRI
SDRI
NaSSA
TCA
MAOi

15

SSRI SE

HANDS
Headache
Anxiety
Nausea
Diarrhea
SEX and sleep

16

what is MoA of SNRI

block reuptake of S and R
- can be good in pain and vasomotor

17

what is good about NDRI

no sex SE

18

what is caution about NDRI

can cause seizures

19

what is SE and use of NaSSA

weight gain, sedation, nausea prevention - can be good for cancer patients

20

problems with TCAs

lots of SE
prolonged QT interval

21

what is only reversible MAOi

moclobemide

22

*** what is first line, second line and thrid line antidepr

1 - SSRI, SNRI, NDRI, NaSSA, moclobemide
2 - TCA, quetapine
3 MAOi

23

what to do when small effect

optimize - increase dose

24

what to do when can't increase dose more

combine - with drug of another class - esp for SE
augment - with different drug

25

what if not working

switch to another

26

what is best treatment for psychotic depresison

ECT

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