Lipids and lipoproteins Flashcards Preview

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Flashcards in Lipids and lipoproteins Deck (28):
1

what is clinical importance of lipoproteins

risk for CHD, stroke, acute pancreatitis

2

what is pathological sig, of lipoproteins

involved in atherosclerosis and vascular degeneration

3

what is physiological sig. of lipoproteins

required for life

4

what is prev. of all CV disease mortality

36%

5

what happens to women after menopause

rates become highr than for men

6

3 main clinical manifestations of atherosclerosis

1. CHD
2. cerebrovascualr disease
3. peripheral arterial disease

7

what is most common death due to CV disease

CHD

8

8 modifiable rsk factors

1. dyslipidemia
2. smoking
3. hypertension
4. diabetes
5. obesity
6. diet
7. thrombogenic factors
8. excercise

9

3 non-modificable ris factors

1. age
2. gender
3. family Hx

10

% of pop with no risk factors

20%

11

what is defines familial hyperchol

TC > 13mmol/L

12

cause of FH

defect in LDL receptor

13

Sx of FH

1. xanthomas
2. fatty tendons

14

what is relat. between chol. and CHD

1.5 ratio - reduce chol by 10, reduce CHD by 15

15

what is primary target to prevent CHD

LDL-c

16

what it ratio between LDL-c and CHD

2:1

17

diff. between LDL and LDL-c

LDL is full ball with Apo-B, while LDL-c is heterogeneous particles

18

what is prob with LDL

invade the endothelium and enter intimal layer

19

what is effect of HDL

seems to be related to lower risk factor

20

what do triglycerides indicate

high - CHD risk
very high - pancreatitis

21

what is not assessed in framingham and how to correct

family history - take score and double

22

3 other lipid-related markers for CHD risk

1. apolipoproteins - apoB-100 and apoA-1
2. LDL size
3. lipoprotein a

23

what are apolipoproteins

main protein of lipoproteins

24

function of apolipoproteins

1. facilitate lipid transport
2. activate 3 enzymes (LCAT, LPL, HTGL)
3. binding to cell surface receptors

25

when is ApoB measure useful

separates patient risk in moderate hypertriglyceridemmia

26

what is non HDLc

total C - HDLc

27

what is C reactive protein

inflammatory marker involved in host defence

28

use of CRP measure

CHD risk biomarker in those with fram. risk score 10-19%

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