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Flashcards in molecular basis of graves Deck (10):
1

2 parts of TSH structure and function

a subunit -
B subunit - give the specific function

2

what is TSH receptor

GCPR

3

what are 2 main parts of TSHR

a unit - outer part
B unit - membrane bound aspect

4

what are 3 parts of a unit on TSHR

1. LRD region where TSH binds
2. C region of 50 AA that can be cleaved off by enzymes

5

what is 2 state model for TSHR

1. closed conformation - inactive and can't be bound
2. Open conformation - satbilized by TSH binding

6

what happens if have mutations at or near stabilizing reagions of TSHR

loss of closed conformation meaning it becomes always active

7

what happens in graves disease

1. TSRH attacked by protease and C peptide is lost
2. reduction of disulfide bridges realsease a subunit
3. freed a units stim. antibodies
4. antibodies then mimic TSH and get hyper thyroidism

8

what are the 2 stimulatory pathways influenced by TSH

1. GsA - GCPR
2. GqA - PLC and IP3

9

what is GsA pathway

1. binding activated adenayn cyclase
2. ATP to cAMP
3. cAMP binds to PKA
4. PKA activates specific protein

10

what is GqA pathway

1. TSHR activation activates phospholipae C via GTP
2. PLC conversion of PIP2 to DAG and IP3
3. IP3 promotes Ca release from ER
4. Ca and DAG activate PKC
5. PKC phosphorylates other proteins

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