Back and limb dev Flashcards Preview

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Flashcards in Back and limb dev Deck (23):
1

tissue sources for intervertebral discs

paraaxial mesoderm

2

direction of dev of vert.

cranio>caudal

3

Tissue dev from the side of somites (3)

1. dorsolateral - dermomyotome - dermis
2. dorsal and ventral - myotome - striated muscle
3. ventromedial - sclerotome -

4

tissue dev from side of myotome

1. dorsal - back muscle
2. ventral - rest of body muscle

5

3 sclerotome directions and their devs.

1. ventomedial - vert. bodies and disc
2. dorsomedial - neural acrches and meninges
3. ventrolateral - transverse process and ribs

6

Disc are segmental or intersegmental

segmental

7

vert. are segmental or intersegmental

inter

8

defects of sclerotome dev (3)

1. hemivert. - lacking somite dev on one side
2. fusions
3. spina bifida - vert arch not formed

9

types of neural tube spina bifida (2)


2. myloschisis - open spinal cord
3. mylomeninggocele - produces sac out skin

10

types of vert spina bifida (3)

1. occulta - small gap
2. meningocele
3. meningomyelocele

11

2 areas of interaction for limb dev

lateral mesoderm and wolfian plate

12

expression of what leads to limb bud dev

FGF-10

13

where does and apical ectodermal ridge (AER) form ?

where dorsal and ventral ectoderm meet

14

3 types of org. involved in limb dev. and area and their signal modelcules

1. proximodistal - AER - FGF
2. craniocaudal - ZPA - SHH
3. dorsoventral - ectoderm - Wnt-7

15

Features of proximodistal org.

cells leaving later become more distal

16

probs of proximodistal org

lack of limb dev - paddle limbs

17

features of craniocaudal dev.

which side up and down

18

probs of craniocaudal dev.

mirror-image duplications

19

features of dorsoventral dev

makes flexors and extensors

20

signal molecules of AER and ZPA

AER - FGF
ZPA - SHH

21

what signal and what tissue start limb bud

FGF-10 in mesoderm

22

toe that is on side of ZPA

little toe or finger

23

what are predecessors of limb tissues

muscles - myotomes
limb bud mesenchyme - bones, tendons, blood vessels

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