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Flashcards in Naturals Deck (30):
1

how many people regularly use natruals

50%

2

when was regulation in place

2004- phased in until 2013

3

what define an NHP

any substance (including synthetically produced) that is for use in disease, for self care and dosed.

4

what is not included in NHP

biologics, tobacco, marijuana, injectables

5

what is approval based on (2)

1. safety
2. efficacy

6

what is safety based on (4)

1. known adverse rxns
2. toxicology
3. previous marketing
4. interactions

7

what are 2 classes to prove efficiacy

1. traditional - has been used for 50 years
2. non-traditional - must provide some evidence

8

what is site licencing

make sure the maker is clean etc

9

what is prosposed mech in echinicea

akamides, glycoproteins, polysaccharides, caffeic acids proposed to have anti-inflammatory and immunomodulatory effects

10

what is evidence for Ech in TREATMENT of colds

no real benefits

11

what is evidence of ECH for prevention of colds

may have 10-20% reduction

12

3 potential cautions of ech

1. theoretical: autoimmune disorders -never
2. adverse allergy
3. drug interactions

13

what is interaction of ech and warfarin

clearance was higher with ech, but no effect on INR

14

potential immune effects of ginseng

1. more helper Tcell
2. more monocyte
3. immunostim. in the aged

15

ginseng for treatment of colds

no studies

16

ginseng for prevention of colds

small reductions in :
1. number of colds
2. number of people with 2+ colds
3. severity
4. number of days with cold

17

major potential SE of ginseng

estrogenergic

18

5 ginseng drug interactions

1. hypoglycemic agents
2. MAOIs -
3. CCBs - longer QT
4. digoxin - may be increased
5. estrogen

19

garlic and cholesterol

no effects

20

garlic and hypertension

may small reduction in BP, but can't really say

21

garlic and colds

reduction in number of cold and days of symptoms, but need more studies

22

garlic drug interactions

1. warfarin - double INR
2. diabetic meds

23

ginger for nausea and vomiting

not enough evidence

24

ginger for motion sickness

may have small to moderate effects

25

ginger and anticoagulants

may have interaction by inhibition of thromboxane synthetase

26

pharmacology of SJW

1. may lower reuptake of serotinin
2. maybe upreg of 5-HT receptors

27

SJW and depression

1. better than placebo
2. as good as other antidepressent
3. less SEs

28

what is SJW best for

mild-moderate depression , not good evidence for severe

29

SJW drug interaction mechanism

induce CYP

30

evidence for african plum tree

moderate effect sizes for BPH

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