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Flashcards in Protozoa Deck (20):
1

4 classes of protozoa

1. amoeba
2. flaggelates
3. ciliates
4. apicomplexans

2

2 types of life cycles

Direct - 1 host
indirect - 2 hosts

3

2 hosts in indirect

definitive - species in which sexually maturing parasite reaches maturity
intermediate - spec, in which larval or non-sexual stages develop

4

6 ways protozoa harm their hosts

1. mechanical
2. resource competition
3. cytotoxicity
4. inflammation
5. immune-mediated
6. malignant transformation

5

3 host responses to protozoa

1. cell mediated - effector cell activation and cytoxins
2. macrophages - phaogcytose and ROS
3. humoral - act on cell wall and ABs neutralize parasite via attachment blockade

6

what are cell and humoral mediated good against

cell - need to clear intracellular protozoa
humoral - enhances cytotoxic and phagocitic potential

7

6 ways to test for protozoa

1. direct examination
2. culture
3. antigen detection - Rapid Diagnostic Test
4. host antibody detection
5. nucleic acid amplification
6. radiologic - liver abscess

8

5 medical ways of treating

1. antibiotics- a couple
2. antifungals - azoles
3. antiparasitics - all protozoa
4. herbs/plant - quinine
5. elements

9

surgical method

percutaneous drainage

10

what is leishmaniasis

in direct in human and sandfly

11

clinical sign of leish

skin ulcer

12

2 different presentations of leish

oglioparasitic - mucocutaneous - Cell mediated defence (Th1)
polyparasitic - diffuse skin and visceral (bad) - antibody mediated

13

4 ways to diagnose

1. direct exam - biopsy
2. culture
3. AB detection - serology
4. Nucleic acid - PCR

14

4 treatments of leish

1. antibiotics
2. antifungals - azoles
3. antiparasitics - no
4. herbs/plant - garlic
5. elements - antimony

15

what is malaria

indirect protozoa in mosquito - then liver - then blood

16

3 ways to diagnose malaria

1. direct exam - blood film
2. antigen detection - RDT
3. nucleic acid - PCR

17

gold standard detection

smear - do again if negative

18

what is RDT test good for finding

P. falciparum

19

3 treatments of malaria

1. AB - doxycycline
2. anti-parasitics - chloroquin
3. plants -quinine

20

what is needed to treat liver stage of malaria in P. ovale

primaquine

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